Abstract
The effect of circulation arrest on the development of stress-induced injuries was studied in Krushinsky—Molodkina rats genetically predisposed to audiogenic seizure. Resuscitated rats were subjected to acoustic stress 1.5 month after circulation arrest. The severity of neurological disorders and the frequency and severity of intracranial hemorrhages increased, while excitability of the central nervous system remained unchanged during stress. Thus, the resistance to stress considerably decreased in rats survived a short-term circulatory arrest due to dysfunction of the autonomic nervous regulation of hemodynamics rather than enhanced excitability of the central nervous system.
Similar content being viewed by others
References
S. G. Vlasov, I. V. Storozhenko, A. M. Khak,et al., Fiziol. Zh. SSSR.,77, No. 4, 52 (1991).
V. G. Korpachev, S. P. Lysenkov, and L. Z. Tel',Pat. Fiziol., No. 3, 78–80 (1982).
L. V. Krushinskii,Animal Behavior Formation under Normal and Pathological Conditions [in Russian], Moscow (1960).
V. A. Negovskii A., M. Gurvich, and E. S. Zolotokrylina,Postresuscitation Disease [in Russian], Moscow (1987).
V. V. Semchenko, S. I. Ereniev, and K. K. Makovetskii.Byull. Eksp. Biol. Med.,121, No. 2, 234–237 (1996).
I. B. Kharchenko, R. Kh. Ziganshin, A. V. Volkov, and V. B. Koshelev, ——ibid.,,123, No. 5, 517–520 (1997).
Principles of Laboratory Animal Science, Eds. L. F. M. Van Zuphen,et al., New York, London (1993).
T. V. Ryasina, V. B. Koshelev, A. L. Krushinsky,et al. Brain Res. 473, 153–156. (1988).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 17–19, June, 2000
Rights and permissions
About this article
Cite this article
Figurina, I.B., Volkov, A.V. & Koshelev, V.B. Decreased tolerance to acoustic stress in late postresuscitation period in Krushinsky-Molodkina rats. Bull Exp Biol Med 130, 627–628 (2000). https://doi.org/10.1007/BF02682088
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02682088