Abstract
Reoganization of sinusoidal cells (endotheliocytes, Kupffer cells, and Ito cells) in the liver microregion of male rat liver exposed to 3,4-benzopyrene was studied. Synchronous activation of the lysosome-vacuole systems in Kupffer cells and endotheliocyte indicates cooperation of these cells in detoxification of benzopyrene and its metabolites. Ito cells lose lipid inclusions and actively proliferate; the appearance of intermediate forms between lipocytes and fibroblasts attests to activation of fibrogenesis in the liver.
Similar content being viewed by others
References
A. P. Bat'yanov,Byull. Eksp. Biol. Med.,90, No. 10, 465–467 (1980).
T. P. Beketova and S. M. Sekamova,Arkh. Patol., No. 10, 83–89 (1983).
V. P. Kazanacheev and M. Ya. Subbotin,Studies on the Theory of General Pathology [in Russian], Novosibirsk (1971).
M. M. Kalashnikova,Byull. Eksp. Biol. Med.,129, No. 1, 4–11 (2000).
D. N. Mayanshii,Kupffer Cell and Mononuclear Phagocyte Function [in Russian], Novosibirsk (1981).
D. N. Mayanskii and I. G. Ursov,Lectures in Clinical Pathology. Manual for Physicians [in Russian], Novosibirsk (1997).
L. E. Panin and N. N. Mayanskaya,Lysosomes: Role in Adaptation and Restoration [in Russian], Novosibirsk (1987).
A. A. Pokrovskii and V. A. Tutel'yan,Lysosomes [in Russian], Moscow (1976).
V. A. Shkurupii,Liver Cell Ultrastructure in Stress [in Russian], Novosibirsk (1989).
R. A. Jones and J. A. Summerfield,Liver Biology and Pathobiology, New York (1982), pp. 507–523
E. R. Weibel,Stereological Methods, L. (1979), Vol. 1.
E. Wisse,J. Ultrastructure Res.,38, No. 5-6, 528–562 (1972).
E. Wisse,Med. Chir. Dig.,6, No. 7, 409–418 (1977).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 12, pp. 696–699, December, 2000
Rights and permissions
About this article
Cite this article
Michurina, S.V., Kolesnikov, S.I., Alisievich, S.V. et al. Effect of 3,4-Benzopyrene on ultrastructure of sinusoidal cells of the liver in adult male rats. Bull Exp Biol Med 130, 1209–1211 (2000). https://doi.org/10.1007/BF02682027
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02682027