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Effect of hyperlipidemia on thymocyte sensitivity to apoptosis in CBA and C57Bl/6 mice

  • Immunology and Microbiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Effects of experimental hyperlipidemia on apoptosis and proliferation of thymocytes in response to mitogens were studied in CBA and C57Bl/6 mice. The concentrations of cholesterol in the serum and thymocyte membranes increased in both mouse strains. Spontaneous and dexamethasone-induced apoptosisin vitro and the proliferative response to phytohemagglutinin and concanavalin A were enhanced in thymocytes from C57Bl/6 mice and suppressed in cells from CBA mice. These data suggest opposite reactions of thymocyte to increased serum cholesterol concentration in these two strains, associated with stimulation and suppression of cell activity.

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References

  1. Methods of Immunology, Ed. G. Friemel [in Russian], Moscow (1990).

  2. A. N. Klimov and N. G. Nikul'cheva,Lipids, Lipoproteins, and Atherosclerosis [in Russian], St. Petersburg (1995).

  3. I. G. Kovaleva and V. M. Dil'man,Fiziologiya Cheloveka,7, No. 1, 120–124 (1981).

    CAS  Google Scholar 

  4. R. V. Petrov, R. M. Khaitov, V. M. Man'ko,et al., Immune Response Control and Regulation [in Russian], Leningrad (1981).

  5. V. S. Posokhov, O. A. Rozenberg, and K. P. Khanson,Byull. Eksp. Biol. Med.,113, No. 2, 136–137 (1992).

    CAS  Google Scholar 

  6. V. P. Puzyreva, R. P. Ogurtsov, A. V. Polevshchikov,et al., Lab. Zhivotnye,2, 90–98 (1995).

    Google Scholar 

  7. Current Protocols in Immunology, Eds. J. E. Coliganet al., New York (1992), vol. 1, pp. 1–16.

  8. H. W. De Jonge, D. H. Dekkers, and J. M. Lamers,Mol. Cell. Biochem.,157, No. 1-2, 199–200 (1996).

    Article  PubMed  Google Scholar 

  9. S. Hartel, F. Ojeda, and H. Diehl,Int. J. Radiat. Biol.,74, No. 5, 607–615 (1998).

    Article  PubMed  CAS  Google Scholar 

  10. B. Paigen, D. Mitchell, K. Reue,et al..Proc. Natl. Acad. Sci. USA,84, 3763–3767 (1987).

    Article  PubMed  CAS  Google Scholar 

  11. A. Roberts and J. S. Thompson,Progr. Biochem. Pharm.,13, 298–305 (1977).

    CAS  Google Scholar 

  12. J. L. Stewart-Philips, J. Lough, and E. Skamene,Clin. Invest. Med.,12, No. 2, 121–126 (1989).

    Google Scholar 

  13. R. K. Studer, P. A. Craven, and F. R. DeRubertis,J. Lab. Clin. Med.,125, No. 1, 86–95 (1995).

    PubMed  CAS  Google Scholar 

  14. E. R. Waelti, R. Glueck, and M. W. Hess,Eur. J. Immunol.,11, No. 10, 846–848 (1981).

    Article  PubMed  CAS  Google Scholar 

  15. P. L. Yeagle,Biochim. Biophys. Acta,822, 267–287 (1985).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    E. P. Kiseleva, V. P. Puzyreva, R. P. Ogurtsov & I. G. Kovaleva

Authors
  1. E. P. Kiseleva
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  2. V. P. Puzyreva
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  3. R. P. Ogurtsov
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  4. I. G. Kovaleva
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Corresponding author

Correspondence to E. P. Kiseleva.

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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 200–202, August, 2000

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Kiseleva, E.P., Puzyreva, V.P., Ogurtsov, R.P. et al. Effect of hyperlipidemia on thymocyte sensitivity to apoptosis in CBA and C57Bl/6 mice. Bull Exp Biol Med 130, 783–785 (2000). https://doi.org/10.1007/BF02681946

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  • DOI: https://doi.org/10.1007/BF02681946

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