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Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Single intraperitoneal injection of melatonin in a dose of 1 mg/kg prevented accumulation of cGMP and intensification of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypobaric hypoxia (12,000 m). Changes in habenular content of cGMP suggest that melatonin prevents hypoxia-induced activation of heme-oxygenase.

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Authors and Affiliations

  1. Bukovinskaya State Medical Academy, Chemovtsy

    I. I. Zamorskii & V. P. Pishak

Authors
  1. I. I. Zamorskii
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  2. V. P. Pishak
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Correspondence to I. I. Zamorskii.

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Translated fromByulleten' Eksperimental" noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 168–171, August, 2000

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Zamorskii, I.I., Pishak, V.P. Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia. Bull Exp Biol Med 130, 756–758 (2000). https://doi.org/10.1007/BF02681937

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  • DOI: https://doi.org/10.1007/BF02681937

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