Abstract
Cholinergic contractile reactions of smooth muscles in rabbit pulmonary arteries were studied by mechanography. The muscarinic receptor agonist pilocarpine induced biphasic relaxation of mesatone- or potassium-precontracted segments from lobar pulmonary arteries with intact endothelium. The low-threshold endothelium-dependent component of pilocarpine-in-duced relaxation was suppressed by denudation or nitric oxide synthese blocker L-NAME.
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L. V. Kapilevich, M. B. Baskakov, I. V. Kovalev, and N. P. Larionov,Akt. Vopr. Kardiol., No. 7, 67–70 (1993).
L. V. Kapilevich, M. B. Baskakov, Ya. D. Anfinogenova,et al., Byull. Eksp. Biol. Med.,126, No. 12, 618–620 (1998).
V. P. Reutov and S. N. Orlov,Fiziol. Cheloveka,19, No. 1, 24–137 (1993).
M. F. Shuba and N. G. Kochemasova,Physiology of Vascular Smooth Muscles [in Russian], Kiev (1988).
C. Braer and C. Emery,Am. J. Physiol.,266, No. 4, Pt. 2. 1–16 (1994).
M. J. Kuchan and J. A. Frangos, ——Ibid.,266, No. 3, Pt. 1, 628–636 (1994).
Pulmonary Vascular Physiology and Pathophysiology, Eds. E. K. Weir and J. T. Reeves, New York (1989).
J. Schemcck and T. Koch,Anasthesiol Intensivmed Notfallmed Schmerzther,32, No. 7, 401–408 (1997).
H. Toyoshima, Y. Nasa, and Y. Hashizume,Thromb. Res.,92, No. 2, 183–189 (1998).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 8, pp. 134–136, August, 2000
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Kapilevich, L.V., Anfinogenova, Y.D., Baskakov, M.B. et al. Peculiarities of cholinergic regulation of smooth muscles in rabbit pulmonary arteries. Bull Exp Biol Med 130, 728–730 (2000). https://doi.org/10.1007/BF02681928
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DOI: https://doi.org/10.1007/BF02681928