Abstract
The study of membrane peroxidation has been carried out using model systems consisting of a polyunsaturated fatty acid monolayer and an unsaturated phosphatidylcholine bilayer system. It has been shown that the major products of lipid peroxidation in monolayer and mixed saturated-unsaturated liposomes are epoxides, hydroxy-epoxides and their hydrolysis products. These same products are found in lungs of rats, particularly after 24 hr of breathing 6 ppm NO2. In all cases, inclusion of tocopherol introduces a lag period during which little peroxidation occurs.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Wu, G.-S., and J.F. Mead, Lipids 12:965 (1977).
Wu, G.-S., R.A. Stein and J.F. Mead, Ibid. 12:971 (1977).
Wu, G.-S., R.A. Stein and J.F. Mead, Ibid. 13:517 (1978).
Wu, G.-S., R.A. Stein and J.F. Mead, Ibid. 14:644 (1979).
Wu, G.-S., R.A. Stein and J.F. Mead, JAOCS 57:145A (1980).
Barber, A.A., Lipids 1:146 (1966).
Mead, J.F., M. Gan-Elepano and F. Hirahara, in “Nitrogen Oxides and Their Effects on Health,” edited by S.D. Lee, Ann Arbor Science, MI, 1980, pp. 191.
Author information
Authors and Affiliations
Additional information
Presented as the acceptance address for the Award in Lipid Chemistry, April 28, 1980, during the ISF/AOCS World Congress.
About this article
Cite this article
Mead, J.F. Membrane lipid peroxidation and its prevention. J Am Oil Chem Soc 57, 393–397 (1980). https://doi.org/10.1007/BF02678922
Issue Date:
DOI: https://doi.org/10.1007/BF02678922