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Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice

  • The Role of Fatty Acids in Gene Expression
  • Published:
Lipids

Abstract

Insulin and dietary fructose independently induce stearoyl-CoA desaturase 1 (SCD1) gene expression in diabetic mouse liver. In the present study, we again used diabetic mice and supplemented a high fructose diet with polyunsaturated fatty acids (PUFA) to determine the selective repression of SCD1 gene expression by dietary PUFA, as previously shown in normal mice. We saw dramatic repression of SCD1 mRNA expression, with trilinolenin at 3% and triarachidonin at 1% supplementation. We also observed significant repression of insulin-induced SCD1 mRNA upon supplementation of the noninducing starch diet with PUFA. In conclusion, our data demonstrate that PUFA negatively regulate hepatic gene expression through an insulin-independent mechanism.

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Abbreviations

SCD1:

stearoyl-CoA desaturase gene 1

SCD2:

stearoyl-CoA desaturase gene 2

PUFA:

polyunsaturated fatty acids

PPAR:

peroxisome proliferator-activated receptors

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Authors and Affiliations

  1. Department of Biochemistry, The University of Wisconsin-Madison, 420 Henry Mall, 53706, Madison, WI

    Katrina M. Waters & James M. Ntambi

Authors
  1. Katrina M. Waters
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  2. James M. Ntambi
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Waters, K.M., Ntambi, J.M. Polyunsaturated fatty acids inhibit hepatic stearoyl-CoA desaturase-1 gene in diabetic mice. Lipids 31, S33–S36 (1996). https://doi.org/10.1007/BF02637047

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