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Expression of proliferationg cell nuclear antigen during the cell cycle of human diploid fibroblasts

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Summary

Proliferating cell nuclear antigen mRNA levels were determined in human diploid fibroblasts as they progressed through the cell cycle. PCNA message levels were low at G0, gradually increased following entrance into G1, peaked at G1/S, and declined during S phase. PCNA mRNA was determined to have a half life of 12 hours when cells were blocked at the G1/S interface. PCNA protein levels increased two- to three-fold as cells moved from G0 to S phase.

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  1. The Samuel Roberts Noble Foundation, Inc., Post Office Box 2180, 73402, Ardmore, Oklahoma

    C. A. Stewart & R. T. Dell’orco

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  1. C. A. Stewart
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  2. R. T. Dell’orco
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Stewart, C.A., Dell’orco, R.T. Expression of proliferationg cell nuclear antigen during the cell cycle of human diploid fibroblasts. In Vitro Cell Dev Biol - Animal 28, 211–214 (1992). https://doi.org/10.1007/BF02631094

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