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Coordinated regulation of vascular endothelial cell growth and prostacyclin production by epidermal growth factor: Evidence of clonal variations among rat aortic endothelial cells

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Summary

Rat aortic endothelial cells were found to exhibit clonal variations in response to EGF stimulation in cell growth and prostacyclin synthesis. EGF-induced growth and prostacyclin synthesis appeared to be regulated in a coordinated manner in that a clone with a higher response to EGF growth stimulation also exhibited a higher response to EGF-stimulated prostacyclin synthesis. This observation implys a possible involvement of prostacyclin synthesis in some of the biological effects of EGF on vascular endothelial cells.

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Authors and Affiliations

  1. Department of Physiology, Chang Gung Medical College, 333, Kweisan, Taoyuan, Taiwan, Rep. of China

    Jan-Kan Chen, Ying-Tung Lau & Jackson Chu

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  1. Jan-Kan Chen
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  2. Ying-Tung Lau
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  3. Jackson Chu
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Chen, JK., Lau, YT. & Chu, J. Coordinated regulation of vascular endothelial cell growth and prostacyclin production by epidermal growth factor: Evidence of clonal variations among rat aortic endothelial cells. In Vitro Cell Dev Biol - Animal 28, 143–145 (1992). https://doi.org/10.1007/BF02631018

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  • DOI: https://doi.org/10.1007/BF02631018

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