Summary
Pieces of lumbar fat pads from fed female rats were incubated in the presence of 1-14C-glycerol. Epinephrine (2.8 µM), glucose (5 mM), tolbutamide, glipentide or glibenclamide were added to the incubation media. The sulfonylurea drugs reduced the lipolytic effect of epinephrine in the absence of glucose; the effect of glibenclamide was greatest. In the absence of epinephrine, both glipentide and glibenclamide reduced the uptake of 1-14C-glycerol and its conversion to glyceride-glycerol while tolbutamide had no effect on these parameters. In the presence of glucose, the lipolytic effect of epinephrine was retained but tolbutamide and glipentide no longer affected glycerol metabolism. Glibenclamide still inhibited the production of glycerol and the utilization of 1-14C-glycerol by the tissues in the presence of glucose. The possibility that sulfonylureas exert their effect on adipose tissue glycerol metabolism by acting as uncoupling agents is discussed.
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Herrera, E. Effects of epinephrine and glucose on the in vitro response of adipose tissue to sulfonylureas. Acta diabet. lat 12, 106–113 (1975). https://doi.org/10.1007/BF02624730
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DOI: https://doi.org/10.1007/BF02624730