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Chronic treatment with thyroid-stimulating hormone. Its effects on blood sugar, serum insulin and free fatty acid levels in normal dogs tested for oral glucose tolerance

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Summary

The effects of bovine TSH (0.1 USP U/kg body weight/die, s.c., for 3–4 days), on blood sugar (BS), serum immunoreactive insulin (IRI) and free fatty acids (FFA) in normal dogs, in basal conditions and during an oral glucose tolerance test were studied. Basal BS, serum IRI and FFA values were not affected by the treatment. Neither were BS and serum FFA levels at any time after glucose loading, over a 3-h period. The insulin response to glucose was fully inhibited by TSH administration: the serum IRI peak was low and non significant. Results are discussed. The inhibitory role of TSH onin vivo insulin secretion is emphasized.

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Authors and Affiliations

  1. Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina

    Aurora Renauld (Established Investigator)

  2. University of Buenos Aires, Argentina

    Liliana L. Andrade (Post-graduate Fellow)

  3. Instituto de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 7° piso, Buenos Aires, Argentina

    Rita C. Sverdlik & Riccardo R. Rodríguez

Authors
  1. Aurora Renauld
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  2. Liliana L. Andrade
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  3. Rita C. Sverdlik
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  4. Riccardo R. Rodríguez
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Additional information

This work, published in abstract form (Comm. No. 86, 8th Congress of the International Diabetes Federation, Brussels, Belgium, July 15–20, 1973), was sponsored by theConsejo Nacional de Investigaciones Científicas y Técnicas, Argentina.

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Renauld, A., Andrade, L.L., Sverdlik, R.C. et al. Chronic treatment with thyroid-stimulating hormone. Its effects on blood sugar, serum insulin and free fatty acid levels in normal dogs tested for oral glucose tolerance. Acta diabet. lat 12, 100–105 (1975). https://doi.org/10.1007/BF02624729

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  • DOI: https://doi.org/10.1007/BF02624729

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