Summary
During thyroxine treatment, A- and B-chains of insulin increased in 8 dogs. Plasma insulin rose, basal blood glucose being virtually unchanged. The A- and B-chain levels may be considered a measure of the degree of insulin breakdown. In hyperthyroid humans, basal plasma insulin was slightly raised. A- and B-chains were consistently raised.
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Orsetti, A., Collard, F. & Jaffiol, C. Abnormalities of carbohydrate metabolism in experimental and clinical hyperthyroidism: Studies on plasma insulin and on the A- and B-chains of insulin. Acta diabet. lat 11, 486–492 (1974). https://doi.org/10.1007/BF02624588
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DOI: https://doi.org/10.1007/BF02624588