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Carbohydrate-induced hyperlipemia in human atherosclerosis

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Summary

Induction of hyperlipemia by high carbohydrate intake has been studied in 20 atherosclerotics. It appeared to be a fairly infrequent occurrence, being successful in only 25% of the patients studied. Induction was positive in 22% of the subjects with normal fasting lipid levels and in 60% of those with type IV hyperlipemia; it failed in the 6 patients with type II A or B hyperlipemia. Induction was not correlated to the degree of carbohydrate tolerance. Therefore, in patients with negative results of induction high triglyceride levels, as those found in types II B and IV, seem to be determined by genetic factors or by nutritional factors other than carbohydrates. Carbohydrate induction is quickly achieved, plasma triglycerides reaching their peak between days 3 and 5. Regression, too, starts early as a rule, sometimes even while the subject is still on the high carbohydrate diet. These findings are evidence of increased VLDL synthesis rather than reduced lipoprotein removal rate. Changes in the triglyceride/protein and triglyceride/cholesterol ratios are indicative of an increased size of both the VLDL and LDL fractions in the course of CHO-induced hyperlipemia.

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Authors and Affiliations

  1. Primario II Divisione Medica, Ospedale Regionale Generale, Venezia, Italy

    Pietro Avogaro, Margherita Pais, Giuseppe Cazzolato & Gianfranco Trabuio

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  1. Pietro Avogaro
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  2. Margherita Pais
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  3. Giuseppe Cazzolato
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  4. Gianfranco Trabuio
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Servizio di Statistica, Ospedale Umberto I, Mestre.

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Avogaro, P., Pais, M., Cazzolato, G. et al. Carbohydrate-induced hyperlipemia in human atherosclerosis. Acta diabet. lat 11, 479–485 (1974). https://doi.org/10.1007/BF02624587

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  • DOI: https://doi.org/10.1007/BF02624587

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