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The HLA system in transplantation immunology

Die Bedeutung des HLA-Systems in der Transplantationsimmunologie

  • Main Topics: Transplantation Surgery
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Abstract

The genetics of the HLA system are described as well as the phenotypic and genomic HLA polymorphisms. The influence of the HLA system in matching for organ transplantation and the tolerance induced by blood transfusion are discussed.

Zusammenfassung

Nach einer Darstellung des genetischen Aufbaus des HLA-Systems sowie der phänotypischen und genomischen HLA-Polymorphismen wird der Einfluß des HLA-Systems für die Empfänger-Spender-Auswahl und die durch Bluttransfusionen induzierte Toleranz diskutiert.

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References

  1. Bjorkman PJ, Saper MA, Samroui B, Bennett WS, Strominger JL, Wiley DC: Structure of the human class I histocompatibility antigen, HLA-A2. Nature 1987;329:506–512.

    Article  PubMed  CAS  Google Scholar 

  2. Bodmer JG, Marsh SGE, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T, Schreuder GMT, Strominger JL, Svejgaard A, Terasaki PI: Nomenclature for factors of the HLA system, 1991. Tissue Antigens 1992; 39:161–173.

    PubMed  CAS  Google Scholar 

  3. Brown JH, Jardetzky T, Saper MA, Samroui B, Bjorkman PJ, Wiley DC: A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature 1988;332:845–850.

    Article  PubMed  CAS  Google Scholar 

  4. Dupont B: Immunobiology of HLA. New York, Springer, 1989.

    Google Scholar 

  5. Lagaaij EL, Hennemann IPH, Ruigrok M, de Han MW, Persijn GG, Termijtelen A, Hendriks GFH, Weimar W, Claas FHJ, van Rood JJ: Effect of one-HLA-DR-antigen-matched and completely HLA-DR-mismatched blood transfusions on survival of heart and kidney allografts. N Engl J Med 1989;321:701–705.

    Article  PubMed  CAS  Google Scholar 

  6. Mayr WR: HLA 1990. Blut 1990;61:207–212.

    Article  PubMed  CAS  Google Scholar 

  7. Olerup O, Zeterquist H: HLA-DRB1 *01 subtyping by allele-specific PCR amplification: a sensitive, specific and rapid technique. Tissue Antigens 1991;37:197–204.

    Article  PubMed  CAS  Google Scholar 

  8. Opelz G, Mytilineos J, Scherer S, Dunckley H, Trejaut J, Chapman J, Middleton D, Savage D, Fischer G, Bignon JD, Bensa JC, Albert E, Noreen H: Survival of DNA HLA-DR typed and matched cadaver kidney transplants. Lancet 1991;338:461–463.

    Article  PubMed  CAS  Google Scholar 

  9. Saiki RK, Bugawan TL, Horn GT, Mullis KB, Erlich HA: Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes. Nature 1986;324:163–166.

    Article  PubMed  CAS  Google Scholar 

  10. Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N: Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 1985;230:1350–1354.

    Article  PubMed  CAS  Google Scholar 

  11. Takemoto S, Terasaki PI: HLA peptide matching. Transplant Proc 1991;23:2039–2042.

    PubMed  CAS  Google Scholar 

  12. Tsuji K, Aizawa M, Sasazuki T: HLA 1991. Oxford, Oxford University Press, 1992.

    Google Scholar 

  13. van Twuyver E, Mooijaart RJD, ten Berge IJM, van der Horst AR, Wilmink JM, Kast WM, Melief CJM, de Waal LP: Pretransplantation blood transfusion revisited. N Engl J Med 1991;325:1210–1213.

    Article  PubMed  Google Scholar 

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Lanzer, G., Felser, B. & Mayr, W.R. The HLA system in transplantation immunology. Acta Chir Austriaca 26, 30–33 (1994). https://doi.org/10.1007/BF02619724

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  • DOI: https://doi.org/10.1007/BF02619724

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