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Inhibition of growth of hamster tumor cells in vitro by pyrrolidone carboxylic acid in a glutamine-dependent system

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Summary

Pyrrolidone carboxylic acid, which is formed spontaneously when glutamine is incubated at 37°C in a phosphate or bicarbonate medium, was found to inhibit growth of a line of hamster tumor cells which required glutamine for survival and growth.

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Authors and Affiliations

  1. Division of Neurosciences, City of Hope National Medical Center, 91010, Duarte, California

    Ingeburg E. Goetz, Constance Weinstein & Eugene Roberts

Authors
  1. Ingeburg E. Goetz
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  2. Constance Weinstein
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  3. Eugene Roberts
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Additional information

This investigation was supported in part by Grant CA-02568 from the National Cancer Institute, Bethesda, Maryland 20014.

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Goetz, I.E., Weinstein, C. & Roberts, E. Inhibition of growth of hamster tumor cells in vitro by pyrrolidone carboxylic acid in a glutamine-dependent system. In Vitro 8, 279–282 (1973). https://doi.org/10.1007/BF02615906

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