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Blocking interleukin-1 receptors

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International Journal of Clinical and Laboratory Research

Summary

During inflammation, injury, immunological challenge or infection, interleukin-1 appears to mediate, in part, the pathogenesis, of disease. Most studies on interleukin-1 are derived from experiments in which bacterial products, such as endotoxins from Gram-negative bacteria or exotoxins from Gram-positive organisms, are used to stimulate macrophagic cells. In general, several cytokines are induced by microbes to their products. Although cytokines are thought to play a role in the outcome of disease, only a few have been directly implicated as mediators of the pathogenic mechanisms of the host. Studies on specific inhibition of interleukin-1 activity have employed interleukin-1 receptor antagonist, interleukin-1 receptors blocking antibodies or soluble interleukin-1 receptors. Experiments in vitro, in animal models of disease and in human subjects have shed considerable light on a critical role for interleukin-1 in the pathogenesis of disease. This review focuses on interleukin-1 as a cytokine of strategic importance to the outcome of disease, particularly inflammatory and infectious diseases.

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  1. Department of Medicine, Tufts University School of Medicine and the New England Medical Center, 750 Washington Street, 02111, Boston, MA, USA

    Charles A. Dinarello

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  1. Charles A. Dinarello
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Dinarello, C.A. Blocking interleukin-1 receptors. Int J Clin Lab Res 24, 61–79 (1994). https://doi.org/10.1007/BF02593903

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  • DOI: https://doi.org/10.1007/BF02593903

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