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Role of Cytokines

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Immunopharmacology

Abstract

This chapter described the physiologic, pharmacologic, and pathologic effects of cytokines. They are glycosylated small polypeptides, synthesized and released by a variety of sources including lymphocytes, leukocytes, and other cell sources. Cytokines are a crucial component of immune response, as they aid in the intercellular communication and are involved in both health and disease, through their physiological and pathological effects. They are involved in mediating natural immunity and regulating the activation, growth, and differentiation of lymphocytes, leukocytes, as well as other cell types. Furthermore, they play a role in the regulation of immune-mediated inflammation and stimulate hematopoiesis. Their effects are mediated via cell surface receptors. Based on their physiological and pathological effects, they are ideal therapeutic agents, either by themselves or as antagonists, which also include specific monoclonal antibodies directed against them.

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  1. Pharmacy Sciences, Creighton University, Omaha, Nebraska, USA

    Manzoor M. Khan

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Khan, M.M. (2016). Role of Cytokines. In: Immunopharmacology. Springer, Cham. https://doi.org/10.1007/978-3-319-30273-7_2

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