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Removal of the outer lines of the citrate multiplet in proton magnetic resonance spectra of the prostatic gland by accurate timing of a point-resolved spectroscopy pulse sequence

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Abstract

Proton MR spectra of a healthy human prostatic gland show a major signal for citrate appearing as an AB-type multiplet. After application of multipulse localization sequences, the outer lines of this multiplet often appear with dispersion line shapes disturbing the baseline and interfering with proper quantification of citrate itself and other nearby resonances. Based upon analytical descriptions of the time evaluation of an AB spin system during a point resolved spectroscopy (PRESS) pulse sequence (90x-τ1,-180y-τ2-180y-t), equations were derived representing the intensity of the absorption and dispersion line shape of the outer lines of the citrate multiplet at the top of echo t=τ2-τ1. From these equations, it was calculated that the outer lines of citrate can be removed almost completely using a PRESS pulse sequence with τ1=11 ms and τ2=60 ms. The theoretical description was confirmed by the almost complete disappearance of the two outer citrate resonances inin vitro andin vivo proton MR spectra acquired with this pulse sequence timing.

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Authors and Affiliations

  1. Department of Radiology, Medical Faculty, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Marinette van der Graaf, Gerrit J. Jager & Arend Heerschap

Authors
  1. Marinette van der Graaf
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  2. Gerrit J. Jager
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  3. Arend Heerschap
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van der Graaf, M., Jager, G.J. & Heerschap, A. Removal of the outer lines of the citrate multiplet in proton magnetic resonance spectra of the prostatic gland by accurate timing of a point-resolved spectroscopy pulse sequence. MAGMA 5, 65–69 (1997). https://doi.org/10.1007/BF02592268

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  • DOI: https://doi.org/10.1007/BF02592268

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