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Carbon dioxide transfer in a membrane blood oxygenator

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Abstract

Rates of desorption of CO2 from bovine blood, as well as bovine serum, aqueous hemoglobin solutions, and water in a flat-plate-type experimental membrane blood oxygenator using silicone rubber and microporous polypropylene membranes were measured. The experimental data showed good agreement with the rigorous theoretical predictions based on an assumption that the CO2 transfer in the liquid phase is facilitated by simultaneous diffusion of bicarbonate ions produced by the instantaneous hydration of CO2 catalyzed by carbonic anhydrase existing in the red cells. Effects of screen turbulence promoters in the liquid channel were also studied. The overall resistance for CO2 transfer in membrane oxygenators including the blood phase resistance is usually smaller than that for oxygen transfer, unless the liquid phase mass transfer resistance is small relative to the membrane resistance. Thus, a membrane oxygenator designed on the basis of oxygen transfer rates will almost always have a sufficient capacity for CO2 transfer.

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Authors and Affiliations

  1. Chemical Engineering Department, Kyoto University, 606, Kyoto, Japan

    Shigeo Katoh & Fumitake Yoshida

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  1. Shigeo Katoh
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  2. Fumitake Yoshida
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Katoh, S., Yoshida, F. Carbon dioxide transfer in a membrane blood oxygenator. Ann Biomed Eng 6, 48–59 (1978). https://doi.org/10.1007/BF02584531

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  • DOI: https://doi.org/10.1007/BF02584531

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