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Regulation of86Rb outflow from pancreatic islets

IV. Effect of cyclic AMP, dibutyryl-cyclic AMP and theophylline

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Summary

Theophylline (1.4 mM), cyclic AMP (1.0 mM) and dibutyryl-cyclic AMP (0.5 mM) decreased86Rb fractional outflow rate from pancreatic islets perifused in the absence of glucose. In the presence of glucose (16.7 mM), however, the same drugs provoked a modest increase in86Rb fractional outflow rate. The increase in86Rb outflow evoked by theophylline in the presence of glucose was suppressed by quinine, suggesting that it may result from an increase in cytosolic Ca2+ concentration. It is proposed that changes in the cyclic AMP content of islet cells may participate in the regulation of K+ conductance by insulin secretagogues.

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  1. Laboratoire de Médecine Expérimentale, Université Libre de Bruxelles, Belgium

    Angelo R. Carpinelli & Willy J. Malaisse

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  1. Angelo R. Carpinelli
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  2. Willy J. Malaisse
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Carpinelli, A.R., Malaisse, W.J. Regulation of86Rb outflow from pancreatic islets. Acta diabet. lat 17, 199–205 (1980). https://doi.org/10.1007/BF02581319

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