Abstract
The effect of glucose upon the handling of K+ by islets of Langerhans removed from normal rats was investigated by measuring both the net uptake of86Rb+ and its efflux from prelabelled islets. The inflow of K+ into islet cells is mediated, in part at least, by an ouabain-sensitive pump. Glucose fails to affect the inflow rate of K+, but it apparently decreases the permeability of islet cells plasma membrane to effluent K+. The glucose-induced change in permeability is a rapid and rapidly reversible phenomenon. Under steady-state conditions, it leads to an increase in the islet cells K+ pool and a decrease of its fractional turnover rate.
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Malaisse, W.J., Boschero, A.C., Kawazu, S. et al. The stimulus secretion coupling of glucose-induced insulin release. Pflugers Arch. 373, 237–242 (1978). https://doi.org/10.1007/BF00580830
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DOI: https://doi.org/10.1007/BF00580830