Summary
The effect of low-dose somatostatin (2.5 µg/min i.v.) on blood sugar, insulin and GH levels (basal and after i.v. 1 mg glucagon) was studied in 7 normal and 10 acromegalic subjects. No changes in basal values were noted in normal subjects, whereas the insulin response to glucagon was partly inhibited and the glucose response enhanced. Basal blood glucose was likewise unaltered in the acromegalics. There was, however, a significant, though unrelated, fall in both insulin and GH. The insulin response to glucagon was inhibited to a greater degree than in normal subjects. It is clear, therefore, that somatostatin can inhibit the insulin response to glucagon, as well as that to the other stimuli for which data are given in the literature. Acromegalic subjects appear to be more sensitive to inhibition of insulin secretion by somatostatin, though no relation between this and the drug’s parallel inhibition of GH secretion can be shown.
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Alberti K. G. M. M., Christensen N., Christensen E. S., Hansen P. A., Iversen J., Lundbæk K., Seyer-Hansen K., Ørskov H.: Inhibition of Insulin Secretion by Somatostatin — Lancet2, 1299, 1973.
Copinschi G., Virasoro E., Vanhaelst L., Leclercq R., Golstein J., L’Hermite M.: Specific Inhibition by Somatostatin of Growth Hormone Release after Hypoglycaemia in Normal Man — Clin. Endocr.3, 441, 1974.
Curry D. L., Bennet L. L.: Dynamics of Insulin Release by Perfused Rat Pancreases. Effects of Hypophysectomy, Growth Hormone, Adrenocorticotropic Hormone and Hydrocortisone — Endocrinology93, 602, 1973.
De Vane G. W., Siler T. M., Yen S. S. C.: Acute Suppression of Insulin and Glucose Levels by Synthetic Somatostatin in Normal Human Subjects — J. clin. Endocr.38, 913, 1974.
Gerich J. E., Lorenzi M., Schneider V., Karam J. H., Rivier J., Guillemin R., Forsham P. H.: Effects of Somatostatin on Plasma Glucose and Glucagon Levels in Human Diabetes Mellitus — New Engl. J. Med.291, 544, 1974.
Gerich J. E., Lorenzi M., Schneider V., Forsham P. H.: Effects of Somatostatin on Plasma Glucose and Insulin Responses to Glucagon and Tolbutamide in Man — J. clin. Endocr.39, 1057, 1974.
Gerich J. E., Lorenzi M., Hane S., Gustafson G., Guillemin R., Forsham P. H.: Evidence for a Physiologic Role of Pancreatic Glucagon in Human Glucose Homeostasis: Studies with Somatostatin — Metabolism24, 175, 1975.
Hall R., Schally A. V., Evered D., Kastin A. J., Mortimer C. H., Tunbridge W. M. G., Besser G. M., Coy D. H., Goldie D. J., McNeilly A. S., Phenekos C., Weightman D.: Action of Growth-Hormone-Release Inhibitory Hormone in Healthy Men and Acromegaly — Lancet2, 581, 1973.
Koerker D. J., Ruch W., Chideckel E., Palmer J., Goodner C. J., Ensinck J., Gale C. C.: Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas — Science184, 482, 1974.
Malaisse W. J., Malaisse-Lagae F., King S., Wright P. M.: Effect of Growth Hormone on Insulin Secretion — Amer. J. Physiol.215, 423, 1968.
Martin J. M., Gagliardino J. J.: Effect of Growth Hormone on the Isolated Pancreatic Islets of Rat in Vitro — Nature (Lond.)213, 630, 1967.
Molinatti G. M., Massara F., Strumia E., Pennisi E., Scassellati G. A., Vancheri L.: Radioimmunoassay of Human Growth Hormone — J. nucl. biol. Med.13, 26, 1969.
Mortimer C. H., Carr D., Lind T., Bloom S. R., Mallinson C. N., Schally A. V., Tunbridge W. M. G., Yeomans L., Coy D. H., Kastin A. J., Besser G. M., Hall R.: Effects of Growth-Hormone Release Inhibiting Hormone on Circulating Glucagon, Insulin, and Growth Hormone in Normal Diabetic, Acromegalic, and Hypopituitary Patients — Lancet1, 697, 1974.
Nelson N.: A Photometric Adaptation of the Somogyi Method for the Determination of Glucose — J. biol. Chem.153, 375, 1944.
Peracchi M., Reschini E., Cantalamessa L., Giustina G., Cavagnini F., Pinto M., Bulgheroni P.: Effect of Somatostatin on Blood Glucose, Plasma Growth Hormone, Insulin, and Free Fatty Acids in Normal Subjects and Acromegalic Patients — Metabolism23, 1009, 1974.
Schatz H., Katsilambros N., Hinz M., Voigt K. M., Nierle C., Pfeiffer E. F.: Hypophysis and Function of Pancreatic Islets. II. The Effect of Substitution with Growth Hormone and Corticotrophin on Insulin Secretion and Biosynthesis of Proinsulin and Insulin in Isolated Pancreatic Islets of Hypophysectomized Rats — Diabetologia9, 140, 1973.
Yen S. S. C., Siler T. M., De Vane G. W.: Effect of Somatostatin in Patients with Acromegaly — New Engl. J. Med.290, 935, 1974.
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Massara, F., Porzio, G., Camanni, F. et al. The effect of somatostatin on plasma insulin and growth hormone levels in basal conditions and after glucagon in normal and acromegalic subjects. Acta diabet. lat 12, 219–231 (1975). https://doi.org/10.1007/BF02581303
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DOI: https://doi.org/10.1007/BF02581303