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Influence of amino acids upon insulin release evoked by 3-phenylpyruvate

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Summary

Insulin release induced by 3-phenylpyruvate in rat pancreatic islets was unaffected by L-norleucine, L-valine, L-alanine and L-asparagine, but potentiated by L-glutamine, glycine and L-serine. The latter two amino acids also enhanced insulin secretion evoked by the combination of 3-phenylpyruvate and L-glutamine. Since 3-phenylpyruvate is known to stimulate insulin release by acting as a transamination partner and facilitating the catabolism of endogenous amino acids, the present findings suggest that the secretory efficiency of such a biochemical sequence depends upon the subcellular location of the transamination reaction and upon the interference of 3-phenylpyruvate with the transport of 2-keto acids into mitochondria.

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Authors and Affiliations

  1. Laboratory of Experimental Medicine, Brussels Free University, Brussels

    Abdullah Sener, Francine Malaisse-Lagae & Willy J. Malaisse

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  1. Abdullah Sener
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  2. Francine Malaisse-Lagae
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  3. Willy J. Malaisse
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Sener, A., Malaisse-Lagae, F. & Malaisse, W.J. Influence of amino acids upon insulin release evoked by 3-phenylpyruvate. Acta diabet. lat 20, 205–209 (1983). https://doi.org/10.1007/BF02581264

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  • DOI: https://doi.org/10.1007/BF02581264

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