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Ultrastructure of the neuro-insular complexes in the pancreas of sand rats (Psammomys obesus)

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Summary

The ultrastructure of the nervous elements in Langerhans islets ofPsammomys obesus has been studied. A great variety of neural structures present in the islets has been described: neuroganglion-, enterochromaffin- and satellite Schwann cells (neuro-insular complexes type I) and cholinergic, adrenergic and peptidergic nerve fibers (neuro-insular complexes type II) in direct contact with the endocrine cells. In the pericapillary space typical neuro-vasal endings of neurosecretory type have been described. The islets of Langerhans and some of the endocrine cells have a total or partial glial sheath. These findings support the thesis of the paraneuronal nature of the endocrine cells of the Langerhans islets.

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References

  1. Andrew A., Kramer B.: An experimental investigation into the possible origin of pancreatic islet cells from rhombencephalic neuroectoderm - J. Embryol. exp. Morph.52, 23, 1979.

    PubMed  CAS  Google Scholar 

  2. Ayer-le Liévre Ch., Fontaine-Perus J.: The neural crest: its relations with APUD and paraneuron concepts - Arch. histol. jap.5, 409, 1982.

    Google Scholar 

  3. Böck P., Gorgas K.: Enterochromaffin cells and enterochromaffin-like cells in the cat pancreas. In:Fujita T. (Ed.): Endocrine gut and pancreas. Elsevier Sci. Publ. Co., Amsterdam, 1976; p. 13.

    Google Scholar 

  4. Dorn A., Bernstein H. -G., Hahn H. -J., Kostmann G., Ziegler M.: Immunohistochemical demonstration of somatostatin-, glucagon- and insulin-like immunoreactivities in the central nervous system of rats, sand rats and genetically diabetic mice (C57 BlKsJ/C57BlKsJ db/db). Verh. anat. Ges. (Jena)75, 791, 1981.

    Google Scholar 

  5. Dorn A., Koch G.: Zur Enzymhistochemie des Pancreas der Sandratten (Psammomys obesus) nach kalorisch differenter Ernährung - Acta histochem. (Jena)57, 212, 1976.

    CAS  Google Scholar 

  6. Dorn A., von Doresche H., Ziegler M.: Immunohistochemischer Nachweis von Insulin und Glucagon in den Langerhansschen Inseln der Sandratten (Psammomys obesus)- Acta histochem. (Jena)53, 317, 1975.

    CAS  Google Scholar 

  7. Fujita T.: Histological studies on the neuro-insular complex in the pancreas of some mammals - Z. Zellforsch.50, 94, 1959.

    Article  Google Scholar 

  8. Fujita T.: The gastro-enteric endocrine cell and its paraneuronic nature. In:Coupland E., Fujita T. (Eds.): Chromaffin, enterochromaffin and related cells. Elsevier Sci. Publ. Co., Amsterdam, 1976, p. 191.

    Google Scholar 

  9. Fujita T., Kobayashi S.: Proposal of a neurosecretory system in the pancreas. An electron microscope study in the dog - Arch. histol. jap.42, 277, 1979.

    PubMed  CAS  Google Scholar 

  10. Haines H., Hackel D. B., Schmidt-Nielsen K.: Experimental diabetes mellitus induced by diet in the sand rat - Amer. J. Physiol.208, 297, 1965.

    PubMed  CAS  Google Scholar 

  11. Havrankova J., Schmeichel D., Roth J., Brownstein M.: Identification of insulin in rat brain - Proc. nat. Acad. Sci. (Wash.)75, 5737, 1978.

    Article  CAS  Google Scholar 

  12. Hoyos-Guevara E.: The pancreatic islet system of the mouse (Mus musculus). Ultrastructural report of six new cell types - Z. Zellforsch.101, 28, 1969.

    Article  PubMed  Google Scholar 

  13. Inage T.: Fluorescence histochemical and electron microscopic observations on the enterochromaffin cells in the dog pancreas. In:Fujita T. (Ed.): Gastro-entero-pancreatic endocrine system. A cell-biological approach. Georg Thieme Verlag, Stuttgart, 1974; p. 96.

    Google Scholar 

  14. Kobayashi S., Fujita T.: Fine structure of mammalian and avian pancreatic islets with special reference to D cells and nervous elements - Z. Zellforsch.100, 340, 1969.

    Article  PubMed  CAS  Google Scholar 

  15. Like A. A., Miki E.: Diabetic syndrome in sand rats. IV. Morphologic changes in islet tissue - Diabetologia3, 143, 1967.

    Article  PubMed  CAS  Google Scholar 

  16. Like A. A., Orci L.: Embryogenesis in the human pancreatic islet: a light and electron microscopic study - Diabetes21 (Suppl. 2), 511, 1971.

    Google Scholar 

  17. Luft J. H.: Fine structure of capillary and endocapillary layer as revealed by ruthenium red - Fed. Proc.25, 1773, 1966.

    PubMed  CAS  Google Scholar 

  18. Malaisse W. J., Like A. A., Malaisse-Lagae F., Gleason R. E., Soeldner J. S.: Insulin secretionin vitro by the pancreas of the sand rats (Psammomys obesus) - Diabetes17, 754, 1968.

    PubMed  CAS  Google Scholar 

  19. Marquié G., Petkov P. E., Donev S., Dahmani Y., Duhault J.: Biochemical and ultrastructural studies of pancreatic islets in a desert rodent, the sand rat (Psammomys obesus) -Proc. int. Union physiol. Sci.14, 2348A, 1980.

  20. Miki E., Like A. A., Soeldner J. S., Cahill G. F.: Acute ketotic-type diabetic syndrome in sand rats (Psammomys obesus) with special reference to the pancreas - Metabolism15, 749, 1966.

    Article  PubMed  CAS  Google Scholar 

  21. Parilla R., Gomez-Acebo J., Candela J. L. R.: Ultrastructural evidence for the presence of enterochromaffin type II cells in the pancreatic islets of the rabbit - J. Ultrastruct. Res.26, 1, 1969.

    Article  Google Scholar 

  22. Pearse A. G. E.: The cytochemistry and ultrastructure of polypeptide hormone producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept - J. Histochem. Cytochem.17, 303, 1969.

    PubMed  CAS  Google Scholar 

  23. Petkov P., Dahmani Y., Donev S., Marquié G.: Morphologie et ultrastructure des ilots de Langerhans d’un rongeur (Psammomys obesus) du Sahara occidental Algérien - Bull. Soc. Hist. natur. Afrique du Nord (Alger)69, 113, 1981.

    Google Scholar 

  24. Petkov P., Hadjiisky P., Marquié G.: Pancreatic islets histochemistry in normal sand rat (Psammomys obesus) - Cell. molec. Biol.6, 655, 1981.

    Google Scholar 

  25. Pictet R. L., Rall L. B., Phelps P., Ruther W. J.: The neural crest and the origin of the insulin-producing and other gastrointestinal hormone producing cells - Science191, 4223, 1976.

    Article  Google Scholar 

  26. Serizawa Y., Kobayashi S., Fujita T.: Neuro-insular complex type I in the mouse. Reevaluation of the pancreatic islet as a modified ganglion - Arch. histol. jap.42, 389, 1979.

    PubMed  CAS  Google Scholar 

  27. Simard L. C.: Les complexes sympathico-insulaires du pancréas de l’homme adulte - C.R. Soc. Biol. (Paris)119, 27, 1935.

    Google Scholar 

  28. Simard L. C.: Les complexes neuro-insulaires du pancréas humain- Arch. Anat. micr. Morph. exp.33, 49, 1937.

    Google Scholar 

  29. Tager H. S., Markese J., Kramer K. J., Speirs R. D., Childs C. N.: Glucagon-like and insulin-like hormones of the insect neurosecretory system - Biochem. J.156, 515, 1976.

    PubMed  CAS  Google Scholar 

  30. van Campenhout E.: Les complexes sympathico-insulaires du pancréas chez l’embryon de mouton - Bull. Ann. Soc. roy. Sci. med. et natur. (Bruxelles) 8–10, 1, 1925.

    Google Scholar 

  31. van Campenhout E.: Contribution à l’étude de l’histogénèse du pancréas chez quelques mammifères. Les complexes sympathico-insulaires - Arch. Biol. (Liège)37, 121, 1927.

    Google Scholar 

  32. von Dorsche H., Titlbach M., Köhler E., Schäfer H.: Elektronenmikroskopische Untersuchungen an Langerhansschen Inseln von Sandratten (Psammomys obesus) von Diabetesmanifestation - Acta histochem. (Jena)68, 254, 1981.

    Google Scholar 

  33. Watari N.: Fine structure of nervous elements in the pancreas of some vertebrates- Z. Zellforsch.85, 291, 1968.

    Article  PubMed  CAS  Google Scholar 

  34. Watari N.: The non-A and non-B cells of the endocrine pancreas. In:Fujita T. (Ed.): Gastro-entero-pancreatic endocrine system. A cell-biological approach. Georg Thieme Verlag, Stuttgart, 1974; p. 71.

    Google Scholar 

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Authors and Affiliations

  1. Katedra po Anatomija, Histologija i Embriologija, Medico-Biological Institute, Sofia

    Stoïtcho Donev & Petko Petkov

  2. Laboratoire de Physiologie Métabolique et de la Nutrition Institut de Biologie, Université des Sciences et de la Technologie, Alger

    Georges Marquié

  3. Institut de Recherches Servier, Suresnes

    Jacques Duhault

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  1. Stoïtcho Donev
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  2. Petko Petkov
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  3. Georges Marquié
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  4. Jacques Duhault
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Donev, S., Petkov, P., Marquié, G. et al. Ultrastructure of the neuro-insular complexes in the pancreas of sand rats (Psammomys obesus). Acta diabet. lat 20, 347–356 (1983). https://doi.org/10.1007/BF02581166

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  • DOI: https://doi.org/10.1007/BF02581166

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