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Serum insulin, insulin antibodies and insulin requirement in the first period of insulin treatment in non-insulin resistant diabetics

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Summary

Twelve insulin-sensitive diabetics were studied for 200 days after the initiation of mixed beef-pork NPH insulin. Normalization of the fasting blood glucose was not accompanied by any elevation in the pre-treatment fasting immunoreactive insulin level. Insulin antibodies appeared in 2 patients on the second week of insulin treatment, in 6 others within 87 days. In 4 patients no antibodies were found 200 days after the start of insulin. The appearance of antibodies was accompanied in two patients by a decrease in insulin requirement, in others there was no change. When antibodies were present, the total maximum insulin binding capacity was 4 to 12 U/1, but the total insulin constituted only 3 to 36% of the binding capacity. Insulin wastage caused by the destruction of the immune complexes was calculated to be 0.35 to 5.6 U/die only, and this explains the negligible effect of insulin antibodies on insulin requirement in non-resistant patients.

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Authors and Affiliations

  1. Diabetic Unit, Department of Internal Medicine ‘D’, Beilinson Medical Center, Petah-Tikva

    Arie Lev-Ran, Leah Ratt & Nili Gersht

  2. Central Laboratory for Endocrinology of the Sick Fund, Esther ha-Malka st. 4, Tel-Aviv, Israel

    Arie Lev-Ran, Leah Ratt & Nili Gersht

  3. Tel-Aviv University Medical School, Israel

    Arie Lev-Ran, Leah Ratt & Nili Gersht

Authors
  1. Arie Lev-Ran
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  2. Leah Ratt
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  3. Nili Gersht
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Lev-Ran, A., Ratt, L. & Gersht, N. Serum insulin, insulin antibodies and insulin requirement in the first period of insulin treatment in non-insulin resistant diabetics. Acta diabet. lat 12, 66–71 (1975). https://doi.org/10.1007/BF02581113

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  • DOI: https://doi.org/10.1007/BF02581113

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