Summary
Insulin-binding antibodies in serum of two groups of diabetics were followed up for a longer period of time. The first group had never been treated with exogenous insulin and showed a low antibody titer, with negligible changes in their level and diminishing of antibody production during ageing. Patients who had received insulin presented some differences: strong dependence of antibody titer on insulin dose; the very high doses, however, as well as a long period of treatment with insulin were accompanied with lowering of antibody concentration.
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References
Andersen O. O.: Insulin Antibody Formation. The Influence of Age, Sex, Infections, Insulin Dosage and Regulation of Diabetes — Acta Endocr. (Kbh.)71, 126, 1972.
Berson S. A., Yalow R. S.: Some Current Controversies in Diabetes Research — Diabetes14, 549, 1965.
Deckert T.: Autoimmunological Aspects of Diabetes Mellitus — Acta med. scand.476 (Suppl.), 29, 1967.
Ditschuneit H., Federlin K.: Die Pathophysiologie der Insulin-Resistenz — Dtsch. med. Wschr.91, 853, 1966.
Ditzov S. P., Penchev I. G., Andreev D. Ch., Sirakov L. M., Tarkolev N. T.: Insulin-Binding Antibodies in Insulin-Treated and Untreated Diabetic Patients — 7th Ann. Meeting Europ. Ass. for the Study of Diabetes, Southampton 1971; abstract # 50.
Ditzov S. P., Penchev I. G., Andreev D. Ch., Tarkolev N. T., Sirakov L. M.: Insulin-Binding Antibodies in Diabetic Patients and their Relationship to Insulin Treatment — Acta diabet. lat.11, 106, 1974.
Følling I., Norman N.: Hyperglycemia, Hypoglycemic Attacks, and Production of Anti-Insulin Antibodies Without Previous Known Immunization. Immunological and Functional Studies in a Patient — Diabetes21, 814, 1972.
Hirata Y., Ishizu H.: Elevated Insulin-Binding Capacity of Serum in a Case with Spontaneous Hypoglycemia and Mild Diabetes Not Treated with Insulin — Tohoku J. exp. Med.107, 277, 1972.
Hurn B. A., Farrant P. C., Yaung B. A., Grahame A.: Insulin-Binding Antibody and Hormone Dosage in Non-Resistant Diabetes — Postgrad. med. J. (Suppl.) 819, 1969.
Kerp L., Kasemir H., Kieling F.: Insulinbindende Antikörper und Insulinbedarf bei Diabetikern — Klin. Wschr.46, 376, 1968.
Kerp L., Steinhilber S., Kasemir H.: Ein Verfahren zum Nachweis insulinbindender Antikörper durch Differentialadsorption — Klin. Wschr.44, 560, 1966.
Nossal G. J. V.: Die Regulation der Immunantwort — Klin. Wschr.47, 568, 1969.
Penchev I., Andreev D., Ditzov S.: Insulin-Precipitating Antibodies in Insulin-Treated and Untreated Diabetic Patients — Diabetologia4, 164, 1968.
Sirakov L. M., Ditzov S. P.: Quantitative Determination of Insulin-Binding Antibodies in Human Serum — Clin. chim. Acta45, 145, 1973.
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Penchev, I.I., Shisheva, A.C., Ditzov, S.P. et al. Insulin-binding antibodies in diabetic patients. Dynamic aspects of their formation. Acta diabet. lat 12, 296–302 (1975). https://doi.org/10.1007/BF02581102
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DOI: https://doi.org/10.1007/BF02581102