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Inhibition of rat mitochondrial functions in vivo by 6-OHDA and reserpine

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Research in Experimental Medicine

Abstract

Reserpine caused a decrease in the state 3, respiratory control ratio (RCR) and ADP/O ratio in frontal cortex, striatum and liver of rats 1 h after drug administration. State 4 respiratory rate was stimulated in frontal cortex and striatum. In the liver, 6-OHDA decreased the ADP/O ratio when both pyruvate/malate and succinate were used as substrates. Reserpine induced changes in the activities of Na+K+-ATPase and Mg2+-ATPase in frontal cortex and liver 15 min and 4 h after administration of the drug. In the liver only 6-OHDA caused the depression of Mg2+-ATPase activity (P<0.05). Reserpine altered the levels of K+, Na+ and Ca2+ cations in rat frontal cortex and striatum, while 6-OHDA caused a decrease in the amount of Mg2+ in liver (P<0.05).

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Authors and Affiliations

  1. Department of Biochemistry, University of Benin, Benin City, Nigeria

    Christopher C. Osubor & Emmanuel A. C. Nwanze

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  1. Christopher C. Osubor
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  2. Emmanuel A. C. Nwanze
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Osubor, C.C., Nwanze, E.A.C. Inhibition of rat mitochondrial functions in vivo by 6-OHDA and reserpine. Res. Exp. Med. 194, 109–117 (1994). https://doi.org/10.1007/BF02576371

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  • DOI: https://doi.org/10.1007/BF02576371

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