Abstract
Five patients with inflammatory lesions received anti-granulocytes murine monoclonal antibody (Mabgc) infused over 5 to 15 min at doses between 3.4 and 5.4 mCi123I (120 μg antibody). Clearance of 1231 from blood pool closely fits a biexponential mathematical model with the two effective half-lives 0.73 h and 9.3 h.
The spontaneous release of 1231 was found to be relatively low in the blood pool. The cumulative urinary excretion of the123I label over 120 h was in the range of 63% of the totally administered dose and is assumed to represent only a low molecular compound or123I alone as iodide. Analysis of the label in spleen, liver and red marrow showed that the concentration of label in these tissues remains more or less constant over a period of 20 h after infusion. With data of liver, spleen, red marrow and whole body activity over a period of 24 h, an estimated radiation dose was calculated.
Compared with111 In labelled leucocytes, especially in spleen, the absorbed dose is lower by a factor of ten per examination.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andres RY, Schubiger PA, Tiefenauer L, Seybold K, Locher JT, Mach JP, Buchegger F (1988) Immunoscintigraphic localization of inflammatory lesions: Concept, radiolabelling and in vitro testing of a granulocyte specific antibody. Eur J Nucl Med 13:582–586
Buchegger F, Schreyer M, Carrel S, Mach JP (1984) Monoclonal antibodies identify a CEA crossreacting antigen of 95 kD (NCA-95) distinct in antigenicity and tissue distribution from the previously described NCA of 55 kD. Int J Cancer 33:643–649
Fueger GF, Schreiner W (1986) Dosimetrie offener Radionuklide. Informatica GmbH, Wien, 337 p
Goodwin DA, Finston R, Smith S (1981) Distribution and dosimetry of In-111 labeled leukocytes and platelets in human. In: Watson EE et al. (eds) Third International Radiopharmaceutical Dosimetry Symposium. Proceedings of a Conference; Oak Ridge, Tenn., October 7-10, 1980, p 88, U.S. Department of Health and Human Services. FDA-81-8166
Marcus C, Stabin MG, Watson EE (1986) Pediatric radiation dose from111In leukocytes. J Nucl Med 27:1220–1221
Snyder WS, Ford MR, Warner GG, Watson SB (1975) “S”, absorbed dose per unit cumulated activity for selected radionuclides and organs. MIRD pamphlet no. 11. Society of Nuclear Medicine, New York
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hasler, P.H., Seybold, K., Andres, R.Y. et al. Immunoscintigraphic localization of inflammatory lesions: Pharmacokinetics and estimated absorbed radiation dose in man. Eur J Nucl Med 13, 594–597 (1988). https://doi.org/10.1007/BF02574775
Issue Date:
DOI: https://doi.org/10.1007/BF02574775