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Neural projections from the frontal cortex to the oculomotor nucleus: an anatomical study using retrograde axonal, anterograde axonal and transneuronal transport of wheat germ agglutinin-conjugated horseradish peroxidase in cats

  • Otoneurology
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Abstract

Neural projections from the frontal cerebral cortex to the oculomotor nucleus (3N) were investigated in 1- to 2-year-old cats by retrograde and anterograde axonal and transneuronal transport of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP). Following injection of WGA-HRP into the 3N area and its surrounding tissues, retrogradely labeled cells were observed in the anterior sigmoid gyrus, ventral bank of the cruciate sulcus, medial and lateral walls and base of the presylvian sulcus, gyrus rectus and gyrus proreus. Following injection of WGA-HRP into these frontal cortical areas, anterogradely labeled nerve terminals were observed in the mesencephalic periaqueductal gray matter (PAG) just overlying the 3N. Only a few terminals were observed within the 3N. Following injection of WGA-HRP into the extraocular muscles of 1-month-old kittens, transneuronally labeled small cells were observed in the PAG just overlying the 3N and in the mesencephalic reticular formation, ventrolateral to it. These small cells may represent intercalated neurons of the cortico-oculomotor projections in the cat.

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Abbreviations

3N :

oculomotor nucleus

4N :

trochlear nucleus

6N :

abducens nucleus

COR :

coronal sulcus

CRU :

cruciate sulcus

DA :

nucleus of Darkschewitsch

FEF :

frontal eye fields

GESA :

anterior ectosylvian gyrus

GPRO :

gyrus proreus

GRE :

gyrus rectus

GSGA :

anterior sigmoid gyrus

GSGP :

posterior sigmoid gyrus

INC :

interstitial nucleus of Cajal

IOS :

inferior oblique subdivision

IRS :

inferior rectus subdivision

IVN :

inferior vestibular nucleus

MRF :

mesencephalic reticular formation

MRS :

medial rectus subdivision

MVN :

medial vestibular nucleus

NPC :

nucleus of the posterior commissure

PAG :

periaqueductal gray matter

PRS :

presylvian sulcus

RN :

red nucleus

SRS :

superior rectus subdivision

SVN :

superior vestibular nucleus

y :

group “y” (of Brodal)

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Author notes

  1. M. Morimoto & T. Kanaseki

    Present address: Department of Anesthesiology, Saga School of Medicine, 840-01, Saga, Japan

Authors and Affiliations

  1. Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, 3-1-1, Maidashi, Higashi-ku, 812, Fukuoka, Japan

    K. Nakao & T. Uemura

  2. Department of Anatomy, Faculty of Medicine, Kyushu University, 812, Fukuoka, Japan

    M. Morimoto & T. Kanaseki

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  1. K. Nakao
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  4. T. Uemura
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Nakao, K., Morimoto, M., Kanaseki, T. et al. Neural projections from the frontal cortex to the oculomotor nucleus: an anatomical study using retrograde axonal, anterograde axonal and transneuronal transport of wheat germ agglutinin-conjugated horseradish peroxidase in cats. Eur Arch Otorhinolaryngol 251 (Suppl 1), S15–S22 (1994). https://doi.org/10.1007/BF02565213

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  • DOI: https://doi.org/10.1007/BF02565213

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