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New developments in phospholipase A2

  • Phospholipases
  • Published:
Lipids

Abstract

Some of the most recent data concerning various phospholipases A2, with special emphasis on secretory, cytosolic, and calcium-independent phospholipases A2 are summarized. Besides their contribution to the production of proinflammatory lipid mediators, the involvement of these enzymes in key cell responses such as apoptosis or tumor cell metastatic potential is also discussed, taking advantage of transgenic models based on gene invalidation by homologous recombination. The possible role of secretory and cytosolic platelet-activating factor acetyl hydrolases is also briefly mentioned. Finally, the ectopic expression in epididymis of an intestinal phospholipase B opens some novel issues as to the possible function of phospholipases in reproduction.

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Abbreviations

MAP kinase:

mitogen-activated protein kinase

mPLB:

membrane phospholipase B

PAF:

platelet-activating factor

PLA2 :

phospholipase A2

mPLB:

phospholipase B

cPLA2 :

cytosolic PLA2

iPLA2 :

calcium-independent PLA2

sPLA2 :

secretory PLA2

TNFα:

tumor necrosis factor α

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Authors and Affiliations

  1. Institut Fédératif de Recherche en Immunologie Cellulaire et Moléculaire, Université Paul Sabatier, France

    Brigitte Chaminade, François Le Balle, Olivier Fourcade, Michel Nauze, Claire Delagebeaudeuf, Ama Gassama-Diagne, Marie-Françoise Simon, Josette Fauvel & Hugues Chap

  2. INSERM Unité 326, Phospholipides Membranaires, Signalisation Cellulaire et Lipoprotéines, Hôpital Purpan, Centre Hospitalo-Universitaire de Toulouse, F 31059, Toulouse Cedex, France

    Brigitte Chaminade, François Le Balle, Olivier Fourcade, Michel Nauze, Claire Delagebeaudeuf, Ama Gassama-Diagne, Marie-Françoise Simon, Josette Fauvel & Hugues Chap

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  1. Brigitte Chaminade
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  2. François Le Balle
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  3. Olivier Fourcade
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  4. Michel Nauze
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  5. Claire Delagebeaudeuf
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  8. Josette Fauvel
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  9. Hugues Chap
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Correspondence to Hugues Chap.

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Chaminade, B., Le Balle, F., Fourcade, O. et al. New developments in phospholipase A2 . Lipids 34 (Suppl 1), S49–S55 (1999). https://doi.org/10.1007/BF02562228

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