Skip to main content
Log in

Dietary fatty acids and coronary heart disease

  • Plenary Lectures
  • Published:
Lipids

Abstract

The effects of dietary fats have been established in epidemiological and intervention studies and through relationship to risk factors for development of coronary heart disease (CHD). During a period where the impressive effects of hydroxymethylglutaryl-CoA reductase inhibitors on the mortality of CHD dominate the medical journals, it is important to realize the major effects of dietary fatty acids on a series of events included in the multifactorial disorder of CHD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

CHD:

coronary heart disease

MUFA:

monounsaturated fatty acid

PUFA:

polyunsaturated fatty acid

References

  1. Scandinavian Simvastatin Survival Study Group (1994) Randomized Trial of Cholesterol-Lowering in 4444 Patients with Coronary Heart Disease: The Scandinavian Simvastatin Survival Study (4S),Lancet 344, 1863–1869.

    Article  Google Scholar 

  2. Shepherd, J., Cobbe, S.M., Ford, I., Isles, C.G., Lorimer, A.R., MacFarlane, P.W., McKilop, J.H., and Packard, C.C. (1995) Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia,N. Engl. J. Med. 20, 1301–1307.

    Article  Google Scholar 

  3. Sacks, F.M., Pfeiffer, M.D., Moye, L.A., Rouleau, J.L., Rutherford, J.D., Cole, T.G., Brown, L., Warnica, J.W., Arnold, J.M.O., Wun, C.-C., Davis, B.R., and Braunwald, E. (1996) The Effect of Pravastatin on Coronary Events After Myocardial Infarction in Patients with Average Cholesterol Levels,N. Engl. J. Med. 334, 1001–1009.

    Article  Google Scholar 

  4. Simes, R.J., Watson, J., Anderson, N., Hankey, G., Simes, S., and Tonkin, A. (1998) Pravastatin Reduces Total Mortality in Patients with Coronary Heart Disease and Average Cholesterol Levels: Relationship of Baseline Cholesterol and Treatment Effect in the LIPID Trial,J. Am. Coll. Cardiac (Abstr.) 31, 1116–1124.

    Google Scholar 

  5. Gould, A.L., Rossouw, J.E., Santanello, N.C., Heyse, J.F., and Furberg, C.D. (1998) Cholesterol Reduction Yields Clinical Benefit,Circulation 97, 946–952.

    PubMed  CAS  Google Scholar 

  6. Verschuren, W.M.M., Jacobs, D.R., Bloemberg, B.P.M., Kromhout, D., Menotti, K., Aravanis, Q., Blackburn, H., Buzinar, R., Dontas, A.S., and Froanza, F. (1995) Serum Total Cholesterol and Long-Term Coronary Heart Disease Mortality in Different Cultures,JAMA 274, 131–136.

    Article  PubMed  CAS  Google Scholar 

  7. Committee on Diet and Health Food and Nutrition Board Commission on Life Sciences National Research Council (1989), inDiet and Health: Implications for Reducing Chronic Disease Risk, pp. 161–168, National Academy Press, Washington, D.C.

    Google Scholar 

  8. Strøm, A., and Jensen, R.A. (1952) Mortality from Circulatory Diseases in Norway,Lancet 1, 126–130.

    Google Scholar 

  9. Keys, A. (1957) Diet and the Epidemiology of Coronary Heart Disease,JAMA 164, 1912–1919.

    CAS  Google Scholar 

  10. Dawber, T.R., Moore, F.E., and Makk, G.V. (1957) Coronary Heart Disease in the Framingham Study,Am. J. Pub. Health 47, suppl. April, 4–24.

  11. Okuyama, H., Kobayashi, T., and Watawabe, S. (1997) Dietary Fatty Acids—the n-6/n-3 Balance and Chronic Elderly Diseases. Excess Linoleic Acid and Relative n-3 Deficiency Syndrome Seen in Japan,Progr. Lipid Res. 35, 409–457.

    Article  Google Scholar 

  12. Dyerberg, J., Bang, H.O., Stoffersen, E., Moncada, S., and Vane, J.R. (1978) Eicosapentaenoic Acid and Prevention of Thrombosis and Atherosclerosis,Lancet 2, 117–119.

    Article  PubMed  CAS  Google Scholar 

  13. Nestel, P.J. (1995) Controlling Coronary Risk Through Nutrition,Am. J. Cardiol. 11, suppl. 6, 9–14.

    Google Scholar 

  14. Hu, F.B., Stampfer, M.J., Manson, J.E., Rinn, E., Colditz, G.A., Rosner, B.A., Hennekens, C.H., and Willett, W.C. (1997) Dietary Fat Intake and the Risk of Coronary Heart Disease in Women,N. Engl. J. Med. 337, 1491–1499.

    Article  PubMed  CAS  Google Scholar 

  15. Esrey, K.L., Joseph, L., and Grover, S.A. (1996) Relationship Between Dietary Intake and Coronary Heart Disease Mortality: Lipid Research Clinics Prevalence Follow-Up Study,J. Clin. Epidemiol. 49, 211–216.

    Article  PubMed  CAS  Google Scholar 

  16. Nordøy, A. (1996) Fish Consumption and Cardiovascular Disease: A Reappraisal,Nutr. Metab. Cardiovasc. Dis. 6, 103–109.

    Google Scholar 

  17. Billman, G.E., Hallag, H., and Leaf, A. (1994) Prevention of Ischemia-Induced Ventricular Fibrillation by θ-3 Fatty Acids,Proc. Natl. Acad. Sci. USA, 91, 4427–4430.

    Article  PubMed  CAS  Google Scholar 

  18. McLennan, P.L., Bridle, T.M., Abeywardena, M.Y., and Charnock, J.S. (1992) Dietary Lipid Modulation of Ventricular Fibrillation Threshold in the Marmoset Monkey,Am. Heart J. 123, 1555–1561.

    Article  PubMed  CAS  Google Scholar 

  19. Sisovick, D.S., Raghuthan, T.E., King, I., Weinman, S., Wicklund, K.G., Albright, J., Boubjerg, M., Arbogast, P., Smith, H., Kushi, L.H., Cobb, L.A., Copass, M.K., Psaty, B.M., Lemaitre, R., Retzlaff, B., Childs, M., and Knopp, R.H. (1995) Dietary Intake and Cell Membrane Levels of Long-Chain n-3 Polyunsaturated Fatty Acids and the Risk of Primary Cardiac Arrest,JAMA 274, 1363–1367.

    Article  Google Scholar 

  20. Burr, M.L., Gilbert, J.F., Holliday, R.M., Elwood, P.C., Fehily, A.M., Rogers, S., Sweetnam, P.M., and Deadman, N.M. (1989) Effects of Changes in Fat, Fish and Fibre Intakes on Death and Myocardial Reinfarction: Diet and Reinfarction Trial (DART),Lancet 2, 757–761.

    Article  PubMed  CAS  Google Scholar 

  21. deLorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J.L., Monjaud, I., Guidollet, J., Touboul, P., and Delaje, J. (1994) Mediterranean Alpha-Linolenic Acid-Rich Diet in Secondary Prevention of Coronary Heart Disease,Lancet 143, 1454–1459.

    Article  Google Scholar 

  22. Multiple Risk Factor Intervention Trial. Research Group (1982) Multiple Risk Factor Intervention Trial,JAMA 248, 1465–1477.

    Article  Google Scholar 

  23. Hjermann, I., Byre, K.V., Holme, I., and Leren, P. (1981) Effect of Diet and Smoking Intervention on the Incidence of Coronary Heart Disease. Report from the Oslo Study Group of a Randomized Trial in Healthy Men,Lancet 2, 1303–1310.

    Article  PubMed  CAS  Google Scholar 

  24. Hjermann, I., Holme, I., and Leren, P. (1986) Oslo Study Diet and Anti-Smoking Trial. Results After 102 Months,Am. J. Med. 80, suppl. 2A, 7–11.

    Article  PubMed  CAS  Google Scholar 

  25. Contacos, C., Barter, P.J., and Sullivan, D.R. (1993) Effect of Pravastatin and θ-3 Fatty Acids on Plasma Lipids and Lipoproteins in Patients with Combined Hyperlipemia,Arterioscler. Thromb. 13, 1755–1762.

    PubMed  CAS  Google Scholar 

  26. Nordøy, A., Bønaa, K.H., Nilsen, H., Berg, R.K., Hansen, J.B., and Ingebretsen, O.C. (1998) Effects of Simvastatin and Omega-3 Fatty Acids on Plasma Lipoproteins and Lipid Peroxidation in Patients with Combined Hyperlipemia,J. Intern. Med. 242, 163–170.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

About this article

Cite this article

Nordøy, A. Dietary fatty acids and coronary heart disease. Lipids 34 (Suppl 1), S19–S22 (1999). https://doi.org/10.1007/BF02562223

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02562223

Keywords

Navigation