Skip to main content

Advertisement

SpringerLink
Log in

Pancreaticobiliary involvement in familial polyposis coli/Gardner's syndrome

  • Published:
Diseases of the Colon & Rectum

Abstract

Adenomatous lesions and carcinoma of the upper gastrointestinal tract, biliary tree, and gallbladder are being reported with increasing frequency in patients with familial polyposis coli or Gardner's syndrome (FPC/GS). A patient with FPC/GS who developed polyps with carcinomain situ of the common bile duct and ampulla of Vater, along with extensive adenomatous changes in the duodenum, gallbladder, extrahepatic bile ducts, and main pancreatic duct is presented. Proliferative lesions, adenomas, and carcinomas should always be considered in the differential in patients with FPC/GS who have symptoms of upper gastrointestinal, biliary or pancreatic disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bussey HJ. Familial polyposis coli. Baltimore: Johns Hopkins University Press, 1975.

    Google Scholar 

  2. Gardner EJ, Richards RC. Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet 1953;5:139–47.

    PubMed  CAS  Google Scholar 

  3. Parks TG, Bussey HJ, Lockhart-Mummery HE. Familial polyposis coli associated with extracolonic abnormalities. Gut 1970; 11:323–9.

    Article  PubMed  CAS  Google Scholar 

  4. Jones TR, Nance FC. Periampullary malignancy in Gardner's syndrome. Ann Surg 1979;148:565–71.

    Google Scholar 

  5. Hoffman DC, Goligher JC. Polyposis of the stomach and small intestine in association with familial polyposis coli. Br J Surg 1971;58:126–8.

    Article  Google Scholar 

  6. Ohsato K, Watanabe H, Itoh H, et al. Simultaneous occurrence of multiple gastric carcinomas and familial polyposis of the colon. J Surg (Jpn) 1974;4:165.

    Article  Google Scholar 

  7. Watanabe H, Enjoji M, Yao T, Ohsato K. Gastric lesions in familial adenomatous coli: their incidences and histologic analysis. Hum Pathol 1978;9:269–83.

    Article  PubMed  CAS  Google Scholar 

  8. Duncan BR, Dohner VA, Priest JH. The Gardner syndrome: need for early diagnosis. J Pediatr 1968;72:497–505.

    Article  PubMed  CAS  Google Scholar 

  9. Ross JE, Mara JE. Small bowel polyps and carcinoma in multiple intestinal polyposis. Arch Surg 1974;108:736–8.

    Article  PubMed  CAS  Google Scholar 

  10. Coffey RJ, Knight CD Jr, Van Heerden JA, Weiland LH. Gastric adenocarcinoma complicating Gardner's syndrome in a North American woman: Gastroenterology 1985;88:1263–6.

    PubMed  Google Scholar 

  11. Lees CD, Hermann RE. Familial polyposis coli associated with bile duct cancer. Am J Surg 1981;141:378–80.

    Article  PubMed  CAS  Google Scholar 

  12. Järvinen HJ, Nyberg M, Peltokallio P. Biliary involvement in familial adenomatous coli. Dis Colon Rectum 1983;26:525–8.

    Article  PubMed  Google Scholar 

  13. Burney B, Assor D. Polyposis coli with adenocarcinoma associated with carcinoma in situ of the gallbladder. Am J Surg 1976; 132:100–2.

    Article  PubMed  CAS  Google Scholar 

  14. Bombi JA, Rives A, Astudillo E, Pera C, Cardesa A. Polyposis coli associated with adenocarcinoma of the gallbladder: report of a case. Cancer 1984;53:2561–3.

    Article  PubMed  CAS  Google Scholar 

  15. Erwald R. Gardner's syndrome with adenoma of the common bile duct. Acta Chir Scand 1984;520 (suppl):63–8.

    CAS  Google Scholar 

  16. Lynch HT, Rozen P, Schuelke GS. Hereditary colon cancer: polyposis and nonpolyposis variants. Ca 1985;35:95–114.

    PubMed  CAS  Google Scholar 

  17. Gardner EJ, Plenk HP. Hereditary pattern for multiple osteomas in a family group. Am J Hum Genet 1952;4:31–6.

    PubMed  CAS  Google Scholar 

  18. Scully RE, Mark EJ, McNeely BV. Case records of the Massachusetts General Hospital. N Engl J Med 1982;307:1566–73.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin

    Richard A. Komorowski M.D. (Associate Professor), Michael G. Tresp M.D. & Stuart D. Wilson M.D.

  2. Department of Pathology, Medical College of Wisconsin, 8700 West Wisconsin Avenue, 53226, Milwaukee, Wisconsin

    Richard A. Komorowski M.D. (Associate Professor), Michael G. Tresp M.D. & Stuart D. Wilson M.D.

Authors
  1. Richard A. Komorowski M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael G. Tresp M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stuart D. Wilson M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

About this article

Cite this article

Komorowski, R.A., Tresp, M.G. & Wilson, S.D. Pancreaticobiliary involvement in familial polyposis coli/Gardner's syndrome. Dis Colon Rectum 29, 55–58 (1986). https://doi.org/10.1007/BF02555290

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02555290

Key words

Search

Navigation