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A comparison of prednisolone enemas with low-dose oral prednisolone in the treatment of acute distal ulcerative colitis

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Diseases of the Colon & Rectum

Abstract

The therapeutic efficacy of prednisolone metasulphobenzoate enemas in the treatment of distal colitis has been compared with that of low-dose oral prednisolone, in a single-blind, cross-over trial. Treatment with steroid enemas resulted in symptomatic and sigmoidoscopic evidence of improvement more frequently than treatment with a dosage of oral steroid calculated to achieve similar plasma prednisolone levels. In addition to demonstrating, for the first time, that prednisolone metasulphobenzoate enemas are effective in the treatment of colitis, this study suggests that their efficacy is due to a local action rather than systemic absorption.

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References

  1. Truelove SC, Witts LJ. Cortisone in ulcerative colitis. Br Med J 1955;2:1041–8.

    PubMed  CAS  Google Scholar 

  2. Matts SGF. Intrarectal treatment of 100 cases of ulcerative colitis with prednisolone-21-phosphate enemata. Br Med J 1961;1:165–8.

    PubMed  CAS  Google Scholar 

  3. Powell-Tuck J, Lennard-Jones JE, May CS, Wilson CG, Paterson JW. Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis. Br Med J 1976;1:193–5.

    Article  PubMed  CAS  Google Scholar 

  4. Lee DAH, Taylor M, James VHT, Walker G. Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema. Gut 1979;20:349–55.

    PubMed  CAS  Google Scholar 

  5. Lee DAH, Taylor M, James VHT, Walker G. Rectally administered prednisolone: evidence for a predominantly local action. Gut 1980;21:215–8.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Gastroenterology Unit, General Infirmary at Leeds, Leeds, England

    I. Hamilton M.B., B.S., I. F. Pinder M.B., B.S., R. J. Dickinson M.D., W. S. J. Ruddell M.D., M. F. Dixon M.D. & A. T. R. Axon M.D.

  2. Department of Pathology, General Infirmary at Leeds, Leeds, England

    I. Hamilton M.B., B.S., I. F. Pinder M.B., B.S., R. J. Dickinson M.D., W. S. J. Ruddell M.D., M. F. Dixon M.D. & A. T. R. Axon M.D.

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  1. I. Hamilton M.B., B.S.
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  2. I. F. Pinder M.B., B.S.
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  3. R. J. Dickinson M.D.
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  4. W. S. J. Ruddell M.D.
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  5. M. F. Dixon M.D.
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  6. A. T. R. Axon M.D.
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Hamilton, I., Pinder, I.F., Dickinson, R.J. et al. A comparison of prednisolone enemas with low-dose oral prednisolone in the treatment of acute distal ulcerative colitis. Dis Colon Rectum 27, 701–702 (1984). https://doi.org/10.1007/BF02554591

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  • DOI: https://doi.org/10.1007/BF02554591

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