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Corticosteroids

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Pediatric Inflammatory Bowel Disease

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Abstract

Glucocorticosteroids have long been first-line treatment to induce remission in Crohn disease and ulcerative colitis in children and adults. Common side effects affecting a range of body functions, occurrence of steroid dependency, as well as current treatment strategies involving early use of corticosteroid-sparing drugs (such as immunomodulators and biologicals) have made corticosteroids less and less popular. The current trend is to minimize or even avoid corticosteroid use in pediatric as well as adult inflammatory bowel disease (IBD). Budesonide, a topical corticosteroid that has a 90 % first-pass effect, can be used both as enteric coated capsule and as enema for specific indications. In this chapter, the working mechanism, efficacy, side effects and pharmacokinetics of “classic” (systemic) as well as topical corticosteroids such as budesonide will be reviewed.

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Author information

Authors and Affiliations

  1. Department of Pediatric Gastroenterology, Erasmus MC-Sophia Children’s Hospital, University Medical Center, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands

    Johanna C. Escher MD, PhD

Authors
  1. Johanna C. Escher MD, PhD
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Correspondence to Johanna C. Escher MD, PhD .

Editor information

Editors and Affiliations

  1. Perelman School of Medicine, The Children’s Hospital of Philadelphia, University of Pennsylvania, 34th St. & Civic Ctr. Blvd., Philadelphia, 19104, Pennsylvania, USA

    Petar Mamula

  2. School of Medicine--Greenville, Pediatric Gastroenterology & Nutrition, University of South Carolina, 200 Patewood Drive, Suite A-140, Greenville, 29615, South Carolina, USA

    Jonathan E. Markowitz

  3. Perelman School of Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, 34th St. & Civic Ctr. Blvd., Philadelphia, 19104, Pennsylvania, USA

    Robert N. Baldassano

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Escher, J.C. (2013). Corticosteroids. In: Mamula, P., Markowitz, J., Baldassano, R. (eds) Pediatric Inflammatory Bowel Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5061-0_30

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  • DOI: https://doi.org/10.1007/978-1-4614-5061-0_30

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-5060-3

  • Online ISBN: 978-1-4614-5061-0

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