Abstract
A randomized controlled trial aimed at comparing the individual efficacy of cephalothin, cefoxitin, and metronidazole in the prevention of postoperative wound infection was performed among 74 colorectal surgical patients. Of 28 patients on cephalothin, seven (25 per cent) developed a postoperative infection, but among 23 patients in each of the other two groups, only one (4 per cent) in each group became infected. These results confirm the primary importance of anaerobes in the causation of postoperative sepsis after colorectal surgery.
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Condon RE, Bartlett JG, Nichols RL, Schulte WJ, Gorback SL, Ochi S. Preoperative prophylactic cephalothin fails to control septic complication of colorectal operations; results of controlled clinical trial: a Veterans Administration cooperative study. Am J Surg 1979;137:68–74.
Willis AT, Ferguson IR, Jones PH, et al. Metronidazole in prevention and treatment of bacteroides infections after appendicectomy. Br Med J 1976;1:318–21.
Willis AT, Ferguson IR, Jones PH, et al. Metronidazole in prevention and treatment of bacteroides infections in elective colonic surgery. Br Med J 1977;1:607–10.
Eykyn SJ, Jackson BT, Lockhart-Mummery HE, Phillips I. Prophylactic preoperative intravenous metronidazole in elective colorectal surgery. Lancet 1979;2:761–4.
Williams JD, Geddes AM, Nevu HV, eds. Cefoxitin: microbiology, pharmacology and clinical use. J Antimicrob Chemother 1978; 4(suppl 4):1–255.
Kass EH, Evans DA. Editorial and introduction. Rev Infect Dis 1979;1:1–3.
Mace AE. Sample-size determination. New York: Reinhold Publishing Corporation, 1964:141–3.
Neu HC. Prophylaxis—has it at last come of age? J Antimicrob Chemother 1979;5:331–3.
Proud G, Chamberlain J. Antimicrobial prophylaxis in elective colonic surgery (letter) Lancet 1979;2:1017–8.
Solberg CO. Systemic antibiotic prophylaxis in surgery. J Antimicrob Chemother 1980;6:427–30.
Downing R, McLeisch AR, Burdon DW, Alexander-Williams J, Keighley MR. Duration of systemic prophylactic antibiotic cover against anaerobic sepsis in intestinal surgery. Dis Colon Rectum 1977;20:401–4.
Nielsen ML, Scheibel JH, Wamberg T. Septic complications in colorectal surgery after 24 hours versus 60 hours of preoperative antibiotic bowel preparation. I. Prospective, randomized; double-blind clinical study. Acta Chir Scand 1978;144:523–6.
Keighley MR, Arabi Y, Alexander-Williams J, Youngs D, Burdon DW. Comparison between systemic and oral antimicrobial prophylaxis in colorectal surgery. Lancet 1979;1:894–7.
Panichi G, Pantosti AL, Marsiglio F, et al. Cephalothin or cefoxitin in appendicectomy? (correspondence) J Antimicrob Chemother 1980;6:801–3.
Ellis CJ. How should we use metronidazole? J Antimicrob Chemother 1980;6:305–7.
Ingham HR, Selkon JB, Sisson PR, Middleton RL. Metronidazole in large-bowel surgery (letter). Lancet 1979;2:902–3.
Ingham HR, Hall CJ, Sisson PR, Tharagonnet D, Selkon JB. The activity of metronidazole against facultatively anaerobic bacteria. J Antimicrob Chemother 1980;6:343–7.
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Panichi, G., Pantosti, A., Giunchi, G. et al. Cephalothin, cefoxitin, or metronidazole in elective colonic surgery?. Dis Colon Rectum 25, 783–786 (1982). https://doi.org/10.1007/BF02553311
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DOI: https://doi.org/10.1007/BF02553311