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The effect of dietary enrichment with fish-oil on urinary excretion of N-acetyl-beta-D-glucosaminidase and renal function in proteinuric patients with primary glomerulopathies

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Abstract

The rate of progression of renal disease depends on many factors including serum lipids and tubulo-interstitial injury. Aim of the study was to see whether fish-oil therapy may affect serum lipids and NAG excretion with urine (a marker of tubular cell damage) in humans with renal disease. The effects of dietary fish-oil fatty acids on the serum lipids, NAG urinary excretion and serum arachidonic acid concentration were examined in thirteen primary glomerulonephritic patients with proteinuria and normal renal function. The regular diet enriched with 1650 mg n−3 polyunsaturated fatty acids (18%: 20∶5; n−3 EPA and 12%: 22∶5; n−3 DHA) was ingested for three months.

At the end of fish-oil enriched diet neither creatinine clearance nor urinary protein excretion changed significantly. But serum concentration of HDL and arachidonic acid increased (48.0±15 vs. 52.0±14; p<0.05), (0.47±0.13 vs. 0.72±0.29; p<0.01), respectively. Simultaneously urine NAG excretion and serum LDL decreased (11.2±7.1 vs. 10.3±7.3; p<0.05), (163.0±57 vs. 149.0±51, p<0.01), respectively. We presume that fish-oil supplementation may have a beneficial effect on renal tubular cells in humans and it could be linked with arachidonic acid metabolism.

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References

  1. Schainuck, L. I., Striker, G. E., Cutler, R. E., Benditt, E. P.: Structural-functional correlations in renal disease. Part II: The correlations.Hum. Pathol., 1, 631 (1970).

    Article  PubMed  CAS  Google Scholar 

  2. Riemenschneider, T., Mackensen-Haen, S., Christ, H., Bohle, A.: Correlation between endogenous creatinine clearance and relative interstitial volume of the renal cortex in patients with diffuse membranous glomerulonephritis having a normal serum concentrationLab. Invest., 43, 145 (1980).

    PubMed  CAS  Google Scholar 

  3. Hamazaki, T., Tateno, S., Shishido, H.: Eicosapentaenoic acid and IgA nephropathy.Lancet, 1, 1017 (1984).

    Article  PubMed  CAS  Google Scholar 

  4. Donadio, J. V.: Omega-3 polyunsaturated fatty acids: A potential new treatment of immune renal disease.Mayo Clin. Proc., 66, 1018 (1991).

    PubMed  CAS  Google Scholar 

  5. Pettersson, E. E., Rekola, S., Berglund, L., Sundqvist, K. G., Angelin, B., Diczfalusy, U., Bjorkhem, I., Bergstrom, J.: Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: A prospective, double-blind, randomized study.Clin. Nephrol., 41, 183 (1994).

    PubMed  CAS  Google Scholar 

  6. Gentile, M. G., Fellin, G., Cofano, F., Delle Fave, A., Manna, G., Ciceri, R., Petrini, C., Lavarda, F., Pozzi, F., D'Amico, G.: Treatment of proteinuric patients with vegetarian diet and fish-oil,Clin. Nephrol., 40, 315 (1993).

    PubMed  CAS  Google Scholar 

  7. Mohrun, D.: Rapid colorimetric assay of beta-galactosidase and N-acetyl-beta-D-glucosaminidase in human urine.Clin. Chim. Acta, 73, 453 (1976).

    Article  Google Scholar 

  8. Gerhardt, K. O., Gehrke, C. W.: Rapid microdetermination of fatty acids in biological materials by gas-liquid chromatography.J. Chromatogr., 143, 335 (1977).

    PubMed  CAS  Google Scholar 

  9. McCreary, D. K., Kossa, W. C., Ramachandran, S., Kurtz, R. R.: A novel and rapid method for the preparation of methyl esters for gas chromatography: Application to the determination of the fatty acids of edible fats and oils.J. Chromatogr. Sci. 16, 329 (1978).

    PubMed  CAS  Google Scholar 

  10. Bilo, H. J. G., Homan van der Heide, J. J., Gans, R. O. B., Donker, A. J. M.: Omega-3 polyunsaturated fatty acids in chronic renal insufficiency.Nephron, 57, 385 (1991).

    Article  PubMed  CAS  Google Scholar 

  11. Leaf, A., Weber, P. C.: Cardiovascular effects of n-3 fatty acids.N. Engl. J. Med., 318, 549 (1988).

    Article  PubMed  CAS  Google Scholar 

  12. Gorlin, R.: The biological actions and potential clinical significance of dietary omega-3 fatty acids.Arch. Intern. Med., 148, 2043 (1988).

    Article  PubMed  CAS  Google Scholar 

  13. Bronsgeest-Schoute, H. C., van Gent, C. M., Luten, C. B.: The effect of various intakes of omega-3 fatty acids on blood lipid composition in healthy subjects.Am. J. Clin. Nutr., 34, 1752 (1981).

    PubMed  CAS  Google Scholar 

  14. Schectman, G., Kaul, S., Kissebah, A. H.: Heterogeneity of low density lipoprotein responses to fish-oil supplementation in hypertriglyceridaemic subjects.Arteriosclerosis, 9, 345 (1989).

    PubMed  CAS  Google Scholar 

  15. Fisher, S., Weber, P. C.: Prostaglandin I is formed in vivo in man after dietary eicosapentaenoic acid.Nature, 307, 165 (1984).

    Article  Google Scholar 

  16. von Schacky, C., Fischer, S., Weber, P. C.: Long-term effects of dietary marine w-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans.J. Clin. Invest., 76, 1626 (1985).

    Article  Google Scholar 

  17. Fisher, S., Weber, P. C.: Thromboxane A and prostaglandin I are formed in man after dietary eicosapentaenoic acid: Identification and quantification by capillary gas chromatography-electron impact mass spectrometry.Biomed. Mass. Spec., 12, 470 (1985).

    Article  Google Scholar 

  18. Price, R. G.: The role of NAG (N-acetyl-beta-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity.Clin. Nephrol., 38, S14 (1992).

    Google Scholar 

  19. Bohle, A., Gise, H. V., Mackensen-Haen, S., Stark-Jakob, B.: The obliteration of the post-glomerular capillaries and its influence upon the function of both glomeruli and tibuli.Klin. Wochenschr. 47, 330 (1981).

    Google Scholar 

  20. Schrier, R. W., Harris, D. C. H., Chan, L., Shapiro, J. I., Caramelo, C.: Tubular hypermetabolism as a factor in the progression of chronic renal failure.Am. J. Kidney Dis., 12, 243 (1988).

    PubMed  CAS  Google Scholar 

  21. Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J. I. I. I., Spur, B. W., Robinson, D. R., Corey, E. J., Lewis, R. A., Austen, K. F.: Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function.N. Engl. J. Med., 312, 1217 (1985).

    Article  PubMed  CAS  Google Scholar 

  22. Endres, S., Ghorbani, R., Kelley, V., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., Shaefer, E. J., Wolff, S. M., Dinarello, C. A.: The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells.N. Engl. J. Med., 320, 265 (1989).

    Article  PubMed  CAS  Google Scholar 

  23. Fox, J., Manitius, J., Dębska-Slizień, A., Rutkowski, B., Nowak, J., Bautembach, S., Owczarzak, A.: Influence of omega-3 acid administration, on plasma lipids, functional status of erythrocyte membrane and function of the kidney in patients with primary glomerulopathies.Przegl. Lek. (in press).

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Authors and Affiliations

  1. Department of Nephrology, Institute of Internal Medicine, Poland

    J. Manitius, B. Sulikowska, J. Fox & B. Rutkowski

  2. Clinical Laboratory, Institute of Internal Medicine, Poland

    E. Ludwiczak & W. Łysiak-Szydłowska

  3. Department of Clinical Biochemistry, Medical University of Gdansk, Poland

    Z. Jakubowski

Authors
  1. J. Manitius
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  2. B. Sulikowska
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  3. J. Fox
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  4. Z. Jakubowski
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  5. E. Ludwiczak
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  6. W. Łysiak-Szydłowska
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  7. B. Rutkowski
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Manitius, J., Sulikowska, B., Fox, J. et al. The effect of dietary enrichment with fish-oil on urinary excretion of N-acetyl-beta-D-glucosaminidase and renal function in proteinuric patients with primary glomerulopathies. International Urology and Nephrology 29, 489–495 (1997). https://doi.org/10.1007/BF02551118

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