Abstract
The effect of intravenous (i.v.) essential amino acids (EAA) in the treatment of acute renal failure was evaluated in 50 patients. Thirty patients (Group A) received daily 13.4 g of i.v. EAA solution [Nephramine® (Don Baxter, McGraw) 250 ml/d]+dopamine i.v. 2 μg/kg/min+20% hypertonic glucose solution 500 ml/d as dompared with twenty patients (Group B) who received dopamine i. v. 2 μg/kg/min+20% hypertonic glucose solution 500 ml/d. In Group A patients showed lower daily increase in blood urea nitrogen (BUN) (p<0.05), higher serum total protein and albumin levels on the 15th day of the posttherapy period (p<0.001), lower complication rate (p<0.005), lower mortality rate (p<0.005) and a reverse relation between serum total protein concentration, duration of oliguria and age (p<0.01, r2=0.26; p<0.001, r2=0.32). These data suggest that treatment of such patients with i.v. EAA solutions significantly improves survival.
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Mocan, M.Z., Mocan, H., Gacar, M.N. et al. Effect of essential amino acid supplementation in acute renal failure. International Urology and Nephrology 27, 503–510 (1995). https://doi.org/10.1007/BF02550090
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DOI: https://doi.org/10.1007/BF02550090