Abstract
At the time of operation advanced carcinomas of the urinary bladder often have developed subclinical metastases. In 20 patients with metastases, inoperable carcinoma of the bladder responded to chemotherapy with a combination of adriamycin and 5-FU. 55% of the patients experienced either a complete or incomplete remission, which lasted long in some cases. In the future, suitable combinations of chemotherapeutics could participate in improving the prognosis of advanced carcinoma of the urinary bladder.
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Burfield, G. D.: Intravenous methotrexate in the treatment of advanced bladder cancer.Br. J. Urol., 44, 121 (1972).
Cross, R. J., Glashan, R. W., Humbrey, C. S., Robinson, M. R. G., Smith, P. H., Williams, R. E.: Treatment of advanced bladder cancer with Adriamycin and 5-Fluorouracil.Br. J. Urol., 48, 609 (1976).
Edland, R. W., Weer, J. B., Ansfield, F. J.: Advanced cancer of the urinary bladder. An analysis of results of radiotherapy and concomitant 5-Fluorouracil: a prospective randomized study of 36 cases.Am. J. Roentgenol., 108, 124 (1970).
EORTC Urological Group B.: The treatment of advanced carcinoma of the bladder with combination of Adriamycin and 5-Fluorouracil.Eur. Urol., 3, 276 (1977).
Fossa, S. D., Gudmudsen, T. E.: Single-drug chemotherapy with 5-Fluorouracil and Adriamycin in metastatic bladder carcinoma.Br. J. Urol., 53, 320 (1981).
Garcia-Giralt E., Auvert, J., Lachand, A. T., Botto, H., Abbou, C., Hannoun, M., Pouillart, P., Palangie, T., Jouve, M., Morin, Ph.: Combined chemotherapy in the management of metastatic bladder cancer.Br. J. Urol., 53, 318 (1981).
Hall, R., Herring, W. D., Gibb, I.: Prophylactic oral methotrexate therapy for multiple superficial bladder carcinoma.Br. J. Urol., 53, 582 (1981).
Herr, J.: Diamminedichloride platinum II in the treatment of advanced bladder cancer.J. Urol., 123, 953 (1980).
Jakse, G., Frommhold, H., Marberger, H.: Combined cisplatinum and radiation therapy in patients with stage T3 and T4 bladder cancer: a pilot study.J. Urol., 129, 502 (1983).
Kaufmann, J. J.: Treatment of carcinoma of the bladder with combined radiotherapy, chemotherapy and surgery.Arch. Surg., 99, 477 (1969).
Laplante, M., Brice, M. H.: The upper limits of hopeful application of radical cystectomy for vesical carcinoma: does nodal metastasis always indicate incurability?J. Urol., 109, 261 (1973).
Martino, S., Samal, B., Al-Sarraf, M.: Phase II study of 5-Fluorouracil and Adriamycin in transitional cell carcinoma of the urinary bladder.Cancer Treat. Rep., 64, 161 (1980).
Merrin, C., Beckley, S.: Adjuvant chemotherapy for bladder cancer with doxorubicin hydrochloride and cyclophosphamide: preliminary report.J. Urol., 119, 62 (1978).
Prout, G. R., Slack, N. H., Bross, I. D. J.: Irradiation and 5-Fluorouracil as adjuvants in the management of invasive bladder carcinoma. A cooperative group after 4 years.J. Urol., 104, 116 (1970).
Ram, M. D.: Complications of radiotherapy for carcinoma of the bladder.Proc. Roy. Soc. Med., 63, 93 (1970).
Skinner, D. G.: Management of invasive bladder cancer: a meticulous pelvic node dissection can make a difference.J. Urol., 128, 34 (1982).
Skinner, D. G., Lierskovsky, G.: Cystectomy with pelvic node dissection compared to preoperative radiation therapy plus cystectomy in management of invasive bladder cancer.J. Urol., 131, 1069 (1984).
Smith, J. A., Jr., Whitmore, W. F. Jr.: Regional lymph node metastasis from bladder cancer.J. Urol., 126, 591 (1981).
Stadie, G., Kuhne, U.: Late results of cystectomy in carcinoma of urinary bladder.Int. Urol. Nephrol., 3, 379 (1972).
Steinberg, J. J., Bracken, R. B., Handel, P. B., Johnson, D. E.: Combination chemotherapy (CISCA) for advanced urinary tract carcinoma. A preliminary report.JAMA, 238, 2282 (1977).
Stoter, C.: Adjuvante Chemotherapie beim invasiven Harnblasenkarzinom.Aktuel. Urol., 15, 336 (1984).
Studer, U. E.: Die Bedeutung der Lymphadenektomie bei der Zystektomie.Eur. Urol., 7, 231 (1984).
Tannoch, I. F., Gospodinowicz, M., Evans, K.: A prospective trial of Methotrexate, Adriamycin and Cyclophosphamide (MAC) in bladder cancer.Cancer, 51, 216 (1983).
Turner, A. G., Durrant, K. R. Malpas, J. S.: A trial of bleomycin versus adriamycin in advanced carcinoma of the bladder.Br. J. Urol., 51, 121 (1979).
Weinstein, S. H., Schmidt, J. D.: Doxorubicin chemotherapy in advanced transitional cell carcinoma.Urology, 8, 336 (1976).
Whitmore, W. F. Jr., Marshall, F.: Radical total cystectomy for cancer of the bladder: 230 consecutive cases five years later.J. Urol., 87, 853 (1962).
Williams, S. D., Rohm, R. J., Donohue, J. P.: Chemotherapy of bladder cancer with cis-DDP, ADR and 5-FU.Proc. Am. Ass. Cancer Res. andASCO, 19, 326 (1978).
Willet, F., Whitmore, W. F. Jr.: Urothelialer Tumor: Probleme und Perspektiven.Eur. Urol., 7, 13 (1984).
Willet, F., Whitmore, W. F. Jr.: Die Behandlung invasiver Harnblasenkarzinome.Eur. Urol., 7, 65 (1984).
Yagoda, A.: Chemotherapy for metastatic bladder cancer.Cancer, 45, 1879 (1980).
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Study by the research group “Clinical Oncology”, FSU, Jena, GDR.
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Stadie, G., Möller, A., Müller, H. et al. Results of systemic chemotherapy of advanced bladder carcinomas (phase II study). International Urology and Nephrology 19, 75–79 (1987). https://doi.org/10.1007/BF02549681
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DOI: https://doi.org/10.1007/BF02549681