Skip to main content
SpringerLink
Log in

Assessment of liver ability to biotransformation of antipyrine in uraemic patients on regular peritoneal dialysis treatment

  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

Abstract

It was the aim of this work to establish whether biotransformation of drugs by the liver expressed by antipyrine kinetics is disturbed in peritoneally dialysed patients with end-stage renal failure. The investigations were carried out in 10 uraemic patients using the antipyrine test and comparing the parameters of antipyrine kinetics with those obtained in 13 healthy persons. Our results indicate that in uraemic patients on regular peritoneal dialysis treatment antipyrine kinetics are generally in the normal range, suggesting the microsomal content of cytochrome P-450 being not evidently reduced.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Adamska-Dyniewska, H., Dziekański, S.: Wpływ labetalolu na wątrobowy metabolizm antypiryny.Pol. Arch. Med. Wewn., 71, 149 (1984).

    PubMed  CAS  Google Scholar 

  2. Adamska-Dyniewska, H., Kowalczyk, L.: Badania nad współzależnością kinetyki antypiryny, zieleni indocyjaninowej i bromosulfoftaleiny u osób zdrowych i z chorobami układu krążenia.Pol. Tyg. Lek., 33, 1144 (1978).

    Google Scholar 

  3. Adamska-Dyniewska, H.: Ocena zdolności wątroby do biotransformacji leków u chorych z przewlekłą niewydolnością, krążenia (kinetyja antypiryny in zieleni indocyjaninowej).Pol. Arch. Med. Wewn., 60, 313 (1978).

    PubMed  CAS  Google Scholar 

  4. Brodie, B., Axelrod, J., Soberman, R., Levy, B.: The estimation of antipyrine in biological material.J. Biol. Chem., 177, 25 (1949).

    Google Scholar 

  5. Brodie, B. B., Axelrod, J.: The fate of antipyrine in man.J. Pharmacol. Exp. Ther., 98, 97 (1950).

    PubMed  CAS  Google Scholar 

  6. Chodera, A., Herman, Z. S.: Clinical Pharmacology. PZWL, Warszawa 1986.

    Google Scholar 

  7. Craig, R. M., Murphy, P., Gibson, T. P., Quintanilla, A., Chao, G. C., Cochrane, C., Patterson, A., Atkinson, A. J. Jr.: Kinetic analysis of D-xylose absorption in normal subjects and in patients with chronic renal failure.J. Lab. Clin. Med., 101, 496 (1983).

    PubMed  CAS  Google Scholar 

  8. Davies, D. S., Thorgeirsson, S. S.: Mechanism of hepatic drug oxidation and its relationship to individual differences in rates of oxidation in man.Ann. N. Y. Acad. Sci., 179, 411 (1971).

    Article  PubMed  CAS  Google Scholar 

  9. Dundee, J., Richards, W. R. K.: Effect of azotemia upon the action of intravenous barbiturate anesthesia.Anesthesiology, 15, 333 (1954).

    Article  PubMed  CAS  Google Scholar 

  10. Fine, A., Summer, D.: Alteration of hepatic acetylation in uraemia.Proc. Eur. Dial. Transplant. Assoc., 11, 433 (1975).

    PubMed  CAS  Google Scholar 

  11. Fraser, H. S., Mucklow, J. C., Bulpitt, C. J., Khan, C., Mould, G., Dollery, C. T.: Environmetal effects on antipyrine half-life in man.Clin. Pharmacol. Ther., 22, 799 (1977).

    PubMed  CAS  Google Scholar 

  12. Gibson, T. P., Atkinson, A. J. Jr., Matusik, E., Nelson, L. D., Briggs, W. A.: Kinetics of procainamide and N-acetylprocainamide in renal failure.Kidney Int., 12, 422 (1977).

    PubMed  CAS  Google Scholar 

  13. Gibson, T. P., Granneman, G. R., Kallał, J. E., Sennello, L. T.: Cefsulodin kinetics in renal impairment.Clin. Pharmacol. Ther., 31, 602 (1982).

    Article  PubMed  CAS  Google Scholar 

  14. Held, H., Enderle, C.: Elimination and serum protein binding of phenylbutazone in patients with renal insufficiency.Clin. Nephrol., 6, 388 (1976).

    PubMed  CAS  Google Scholar 

  15. Leber, H. W., Gleumes, L., Schütterle, G.: Enzyme induction in the uremic liver.Kidney Int., 13, 43 (1978).

    Google Scholar 

  16. Leber, H. W., Harders, A., Schütterel, G.: Untersuchungen zum Einfluss der Urämie auf die Metabolisierung von Phenylbutazon und Aminophenazon beim Menschen.Klin. Wochenschr., 50, 1092 (1972).

    Article  PubMed  CAS  Google Scholar 

  17. Lichter, M., Black, M., Arias, I. M.: The metabolism of antipyrine in patients with chronic renal failure.J. Pharmacol. Exp. Ther., 187, 612 (1973).

    PubMed  CAS  Google Scholar 

  18. Maddocks, J. L.: Increased drug metabolism in chronic renal failure.Proc. Eur. Dial. Transplant. Assoc., 13, 624 (1976).

    Google Scholar 

  19. Orzechowska-Juzwenko, K., Bolanowski, M., Gruszka, S., Szymczak, J.: Farmakokinetyka fenazonu jako wskażnik wydolności metabolicznej wątroby u chorych na nadczynność tarczycy.Pol. Tug. Lek., 38, 643 (1983).

    CAS  Google Scholar 

  20. Quintanilla, A. P.: Liver dysfunction in dialysis patients.Int. J. Artif. Organs, 9, 1 (1986).

    PubMed  CAS  Google Scholar 

  21. Reidenberg, M. M., Kostenbauder, H., Adams, W. P.: Rate of drug metabolism in obese volunteers before and during starvation and in azotemic patients.Metabolism, 18, 209 (1969).

    Article  PubMed  CAS  Google Scholar 

  22. Soberman, R., Brodie, B. B., Levy, B. B., Axelrod, J., Hollander, Y., Steele, J. M.: The use of antipyrine in measurement of total body water in man.J. Biol. Chem., 179, 31 (1949).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Nephrology and Clinical Pharmacology, K. Marcinkowki Academy of Medicine, Poznań, Poland

    A. Grzegorzewska, Z. Ŀowicki, E. Chmara, A. Mrozikiewicz & K. Bączyk

Authors
  1. A. Grzegorzewska
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. Ŀowicki
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Chmara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Mrozikiewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Bączyk
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grzegorzewska, A., Ŀowicki, Z., Chmara, E. et al. Assessment of liver ability to biotransformation of antipyrine in uraemic patients on regular peritoneal dialysis treatment. International Urology and Nephrology 21, 541–545 (1989). https://doi.org/10.1007/BF02549593

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02549593

Keywords

Search

Navigation