Abstract
The thermal effect due to the interaction between human platelets and α,β poly(N-hydroxy-ethyl)-DL-aspartamide (PHEA) or the PHEA-Diflunisal conjugate was measured by the calorimetric technique at 25°C. The experimental data confirm that PHEA is a biocompatible macromolecule and that its conjugate influences the physiological activity of human platelets.
Zusammenfassung
Mittels einer kalorimetrischen Methode wurde der thermische Effekt im Zusammenhang mit der Wechselwirkung zwischen Thrombozyten des Menschen und α,β-Poly(N-hydroxyethyl)-DL-Aspartamid PHED-Diflunisal-Konjugat gemessen. Die experimentellen Daten zeigen, daß PHEA ein biokompatibles Makromolekül ist und daß sein Konjugat die physiologische Aktivität der Thrombozyten beeinflußt.
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References
R. Duncan and J. Kopeček, Adv. Polym. Sci., 57 (1984) 51.
D. R. Friend and S. Pangburn, Med. Res. Rev., 7 (1987) 53.
G. Giammona, B. Carlisi, G. Pitarresi, G. Cavallaro and V. Turco Liveri, J. Controlled Release, 22 (1992) 129.
G. Antoni, C. Arezzini, F. Cocola, G. Gazzei and P. Neri, Il Farmaco Ed. Pr., 34 (1979) 146.
G. Giammona, B. Carlisi, G. Pitarresi and G. Fontana, J. Bioactive Compatible Polymers, 6 (1991) 129.
L. Cavallini and G. Lucchetti, Gazz. Med. Ital., 134 (1975) 7.
I. G. Otterness and M. L. Bliven, in ‘Nonsteroidal Anti-Inflammatory Drugs’, J. G. Lombardino (ed.) John Wiley and Sons, New York (1985).
Ph. Kaklamanis, P. Sfikakis, P. Demetriades, P. Tsachalos, B. Thouas and B. Seitanes, Clinical Therapeutics, 1 (1978) 20.
R. N. Brodgen, R. C. Heel, G. E. Pakes, T. M. Speight and G. S. Avery, Drugs, 19 (1980) 84.
G. Giammona, G. Cavallaro, G. Pitarresi, C. Ventura and S. Palazzo, (sent for publication).
J. B. Smith, and A. L. Willis, Nature [New Biol.] 231 (1971) 235.
S. H. Ferreira, S. Moncada and J. R. Vane, Nature [New Biol.], 231 (1971) 237.
W. Dawson and D. A. Willoughby, Inflammation—Mechanism and mediators', in: ‘Nonsteroidal antiinflammatory drugs’, J. G. Lombardino, (ed.) John Wiley and Sons, New York 1985.
R. J. Flower, S. Moncada and J. R. Vane, The pharmacological basis of therapeutics. A. G. Goodman, L. S. Goodman and A. Gilman, eds. Macmillan Publishing Co., Inc. 1980.
G. Giammona, B. Carlisi and S. Palazzo, J. Polym. Sci. Polym. Chem. Ed., 25 (1987) 893.
Technical Manual, American Association of Blood Banks, Ortho Diagnostic System, Milano 1985.
E. Ascari, U. Torelli and E. Storti, Ematologia, Fisiologia della piastrina. Unione Tipografico-Editrice Torinese, 1992. p. 913.
G. Giammona, B. Carlisi, G. Cavallaro, I. Donato, F. Pinio and V. Turco Liveri, Int. J. Pharm., 54 (1990) 239.
B. Carlisi, G. Cavallaro, G. Giammona, G. Pitarresi, M. L. Turco Liveri and V. Turco Liveri, Boll. Chim. Farm., 131 (1992) 189.
G. Cavallaro, G. Giammona, G. La Manna, S. Palazzo, G. Pitarresi and V. Turco Liveri, Int. J. Pharm. 90 (1992) 195.
G. Cavallaro, G. Giammona, G. La Manna, S. Palazzo, G. Pitarresi and V. Turco Liveri, J. Thermal Analysis, 42 (1994) 869.
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Arcoleo, V., Cavallaro, G., La Manna, G. et al. Calorimetric investigation of the interaction between a macromolecular prodrug of diflunisal and human platelets. Journal of Thermal Analysis 44, 1487–1491 (1995). https://doi.org/10.1007/BF02549234
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DOI: https://doi.org/10.1007/BF02549234