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Maintenance by cortisone of the calcemic response to parathyroid extract of rats on a diet without vitamin D and low in calcium

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Abstract

Weanling rats raised for 21 days on a vitamin D deprived, low Ca diet (0.02%), and given chronic cortisone administration (5 mg/kg/d), maintain responsiveness to the hypercalcemic effect of endogenous and exogenous parathyroid extract (PTE). The PTE action is a bone effect that does not require the presence of the kidneys, and is not related to a higher concentration of calcium or cortisone. Maintained sensitivity of D− Ca− Cort+ rats to PTE does not appear to be the consequence of a lesser degree of D-deficiency: the whole body vitamin D pool and its chloroform-soluble fraction in these animals are not different from those of their D− Ca− PTE− unresponsive controls. Repeated PTE injections for 4 days exhaust the sensitivity to the hypercalcemic action of PTE of D− Ca− Cort+ rats. The present data seem to indicate that cortisone-treated D− Ca− rats, responsive to the bone action of PTE, are characterized by a near normal bone calcium content and Ca/P ratio, and a significant increase in the number of osteoclasts.

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Authors and Affiliations

  1. Laboratoire des Tissus Calcifiés (CNRS ER 126) and Unité de Recherches sur les Maladies du Métabolisme chez l’Enfant, Hôpital des Enfants Malades, Paris

    H. Pavlovitch, G. Witmer, J. Bertret, V. Presle & S. Balsan

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  1. H. Pavlovitch
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  2. G. Witmer
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  3. J. Bertret
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  4. V. Presle
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  5. S. Balsan
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Pavlovitch, H., Witmer, G., Bertret, J. et al. Maintenance by cortisone of the calcemic response to parathyroid extract of rats on a diet without vitamin D and low in calcium. Calc. Tis Res. 20, 261–274 (1976). https://doi.org/10.1007/BF02546414

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  • DOI: https://doi.org/10.1007/BF02546414

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