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Early effects of synthetic bovine parathyroid hormone and synthetic salmon calcitonin on urinary excretion of cyclic AMP, phosphate and calcium in man

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Abstract

Bovine synthetic parathyroid hormone infused intravenously in man increased both the urinary excretion of cyclic AMP and the urinary excretion of phosphate whereas a Salmon synthetic calcitonin infusion increased the urinary excretion of phosphate without change in urinary excretion of cyclic AMP. These data are consistent with the hypothesis that different renal mechanisms are involved in the response to each hormone.

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References

  1. Ardaillou, R., Fillastre, J. P., Milhaud, G.: Renal excretion of phosphate, calcium and sodium during and after a prolonged thyrocalcitonin in man. Proc. Soc. exp. Biol. (N.Y.)131, 56–60 (1960)

    Google Scholar 

  2. Caniggia, A., Gennari, C., Piantelli, F., Vattimo, A.: Initial increase of plasma radioactive calcium after intravenous injection of calcitonin in man. Clin. Sci.43, 171–180 (1972)

    PubMed  CAS  Google Scholar 

  3. Caniggia, A., Gennari, C.: Early effects of calcitonin in man: comparison with the early effects of parathyroid hormone. The 5th parathyroid conference, Oxford July 21–26 1974 (in press)

  4. Caniggia, A., Gennari, C.: The effect of calcitonins on bone47Calcium radioactivity in man (Czitober, H., Eschberger, J. ed.): Proceedings of the ICth European Symposium on Calcified Tissues, Baden (Austria), October 1st–6th, 1972, p. 131. Vienna: Facta Publication 1973

    Google Scholar 

  5. Chase, L. R., Aurbach, G. D.: Parathyroid function and the renal excretion of 3′5′-adenylic acid. Physiology58, 518–525 (1967)

    CAS  Google Scholar 

  6. Chase, L. R., Aurbach, G. D.: Renal adenyl cyclase: anatomically separate sites for parathyroid hormone and vasopressin. Science159, 545–546 (1968)

    Article  PubMed  CAS  Google Scholar 

  7. Cochran, M., Peacock, M., Sachs, G., Nordin, B. E. C.: Renal effects of calcitonin. Brit. Med. J.1, 135–137 (1970)

    Article  PubMed  CAS  Google Scholar 

  8. Fiske, C. H., Subbarow, Y.: The colorimetric determination of phosphorus. J. biol. Chem.66, 375–400 (1925)

    CAS  Google Scholar 

  9. Kaminsky, N. I., Broadus, A. E., Hardman, J. G., Jones, D. J., Ball, J. H., Jr., Sutherland, E. W., Liddle, G. W.: Effects of parathyroid hormone on plasma and urinary adenosine 3′,5′-monophosphate in man. J. clin. Invest.49, 2387–2395 (1970)

    Article  PubMed  CAS  Google Scholar 

  10. Langer, B., Peytremann, A., Rufener, C., Jenny, M.: Effets comparés de l’administration d’une dose unique de calcitonine synthétique (de type humain et de type saumon), chez l’homme normal et les sujets atteints de maladie de Paget ou d’hypercalcémie. Schweiz. med. Wschr.101, 69–80 (1971)

    PubMed  CAS  Google Scholar 

  11. Murad, F.: Clinical studies and application of cyclic nucleotides. In: Greengard, P., Robison, G. A. (eds.): Advances in cyclic nucleotide research, vol. 3, p. 355. New York: Raven Press 1973

    Google Scholar 

  12. Murad, F., Brewer, H. B., Vaughan, M.: Effect of thyrocalcitonin on adenosine 3′,5′-cyclic phosphate formation by rat kidney and bone. Proc. nat. Acad. Sci. (Wash.)65, 446–453 (1970)

    Article  CAS  Google Scholar 

  13. Nagata, N., Rasmussen, H.: Parathyroid hormone and renal cell metabolism. Biochem. (Wash.)7, 3728–3733 (1968)

    CAS  Google Scholar 

  14. Nordquist, R. E., Palmieri, G. M. A.: Intracellular localization of parathyroid hormone in the kidney. Endocrinology95, 229–237 (1974)

    Article  PubMed  CAS  Google Scholar 

  15. Paillard, F., Ardaillou, R., Malendin, H., Fillastre, J. P., Prier, S.: Renal effects of salmon calcitonin in man. J. Lab. clin. Med.80, 200–216 (1972)

    PubMed  CAS  Google Scholar 

  16. Scurry, M. T., Pauk, G. L.: Renal tubular localization of parathyroid hormone induced urinary cyclic adenosine 3′,5′-monophosphate. Acta endocr. (Kbh.)77, 282–286 (1974)

    CAS  Google Scholar 

  17. Tenenhouse, A., Rassmussen, H.: Parathyroid hormone and thyrocalcitonin (calcitonin), Talmage, R. V., Bélanger, L. P. (ed.), p. 392. Amsterdam: Excerpta Medica Foundation 1968

    Google Scholar 

  18. Tomlinson, S., Barling, P. M., Albano, J. D. M., Brown, B. L., O’Riordan, J. L. H.: The effects of exogenous parathyroid hormone on plasma and urinary adenosine 3′,5′-cyclicmonophosphate in man. Clin. Sci. Mol. Med.47, 481–492 (1974)

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Medical Pathology, University of Siena, 53100, Siena, Italy

    A. Caniggia, C. Gennari, A. Vattimo, P. Nardi, R. Nuti & M. Galli

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  1. A. Caniggia
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  2. C. Gennari
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  3. A. Vattimo
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  4. P. Nardi
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  5. R. Nuti
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  6. M. Galli
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Caniggia, A., Gennari, C., Vattimo, A. et al. Early effects of synthetic bovine parathyroid hormone and synthetic salmon calcitonin on urinary excretion of cyclic AMP, phosphate and calcium in man. Calc. Tis Res. 20, 209–215 (1976). https://doi.org/10.1007/BF02546409

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  • DOI: https://doi.org/10.1007/BF02546409

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