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Microbial transformation of 12-hydroxyoctadecanoic acid to 5-n-hexyl-tetrahydrofuran-2-acetic acid

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Journal of the American Oil Chemists’ Society

Abstract

Stationary-phase cells of a corynebacterium (FUI-2) and a bacillus (NRRL B-14864) isolate, when grown aerobically in 1% YE medium at 25°C, converted 12-hydroxystearic acid to a major compound, 5-n-hexyl-tetrahydrofuran-2-acetic acid, and other intermediate and minor compounds (6-hydroxydodecanoic acid, 4-hydroxydecanoic acid, 4-ketodecanoic acid and γ-decanolactone). The yields of 5-n-hexyl-tetrahydrofuran-2-acetic acid, 4-hydroxydecanoic acid, and γ-decanolactone, byBacillus lentus NRRL B-14864 were 43%, 18% and 5%, respectively, after 2.5 d of incubation.

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Authors and Affiliations

  1. Department of Chemistry, Western Illinois University, 61455, Macomb, Ilinois

    J. -K. Huang, J. Zhao, W. E. Klopfenstein & L. Wen

  2. Department of Biological Science, Western Illinois University, 61455, Macob, Illinois

    K. C. Keudell

  3. Department of Oil Chemical Research, NCAUR, ARS, USDA, 61604, Peoria, Illinois

    M. O. Bagby & A. C. Lanser

  4. Department of Bioactive Constituents Research, NCAUR, ARS, USDA, 61604, Peoria, Illinois

    R. D. Plattner & R. E. Peterson

  5. Department of New Crops Research, NCAUR, ARS, USDA, 61604, Peoria, Illinois

    T. P. Abbott

  6. Department of Analytical Chemistry Support, NCAUR, ARS, USDA, 61604, Peoria, Illinois

    D. Weisleder

Authors
  1. J. -K. Huang
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  2. K. C. Keudell
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  3. J. Zhao
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  4. W. E. Klopfenstein
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  5. L. Wen
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  6. M. O. Bagby
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  8. R. D. Plattner
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  9. R. E. Peterson
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Huang, J.K., Keudell, K.C., Zhao, J. et al. Microbial transformation of 12-hydroxyoctadecanoic acid to 5-n-hexyl-tetrahydrofuran-2-acetic acid. J Am Oil Chem Soc 72, 323–326 (1995). https://doi.org/10.1007/BF02541090

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  • DOI: https://doi.org/10.1007/BF02541090

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