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Calculations concerning the response of human cells in tissue culture to X-irradiation at various oxygen concentrations

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Summary

Data derived byBarendsen (1961) on the damage to the reproductive capacity of human cells in tissue culture by ionizing radiation have been subjected to probit analysis. There is no conflict with the hypothesis that the fractions of surviving cells and the log oxygen concentration can be adequately represented by the equation of a cumulative normal curve between the limits (1-P M ) r and (1-P N ) r . (1-P M ) r represents the fraction of cells surviving a radiation doser applied in the presence of 100% oxygen and (1-P N ) r represents the fraction surviving in the absence of oxygen.

In contradiction to expectation the probit regression lines of the two series of tests are not parallel.

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References

  • Barendsen, G. W., 1961. Damage to the Reproductive Capacity of Human Cells in Tissue Culture by Ionizing Radiations of Different Linear Energy Transfer. In: “The Initial Effects of Ionizing Radiations on Cells”, p. 183. Ed. byHarris, R. J. C. New York.

  • Finney, D. J. 1952. Probit Analysis. 2nd Ed. Cambridge.

  • Finney, D. J. andStevens, W. L. 1948. Biometrika35, 191.

    Article  Google Scholar 

  • Howard-Flanders, P. andAlper, T. 1957. Radiation Research7, 518.

    Article  PubMed  CAS  Google Scholar 

  • Van Soestbergen, A. A. 1962a. Int. J. Radiobiol. In press.

  • Van Soestbergen, A. A. 1962b. Int. J. Radiobiol. In press.

  • van Soestbergen, A. A. 1962c. Biochim. Biophys. Acta.60, 653.

    Article  PubMed  Google Scholar 

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Author notes

  1. A. A. Van Soestbergen

    Present address: Mercy Hospital, 2221 Madison Avenue, Toledo, Ohio, USA

Authors and Affiliations

  1. Medical Biological Laboratory of the National Defence Research Organization T.N.O., Rijswijk (Z.H.), The Netherlands

    A. A. Van Soestbergen

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  1. A. A. Van Soestbergen
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Van Soestbergen, A.A. Calculations concerning the response of human cells in tissue culture to X-irradiation at various oxygen concentrations. Antonie van Leeuwenhoek 28, 405–410 (1962). https://doi.org/10.1007/BF02538755

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  • DOI: https://doi.org/10.1007/BF02538755

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