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Effects of highly hydrogenated soybean oil and cholesterol on plasma, liver cholesterol, and fecal steroids in rats

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Lipids

Abstract

We investigated the relationship between dietary highly hydrogenated soybean oil (HSO) and cholesterol transport in rats. In the first study, to examine the effects of cholesterol transport of different concentrations of HSO in dietary oil, rats were given one of the three diets containing 0, 25, or 50% HSO in dietary oil with cholesterol (5 g/kg diet) or a diet without HSO and cholesterol for 22 d. Feeding the high concentration of HSO prevented the increase in plasma total cholesterol, hepatic total lipids, and cholesterol and the decrease in high-density lipoprotein-cholesterol, which were caused by dietary cholesterol. Moreover, HSO increased the fecal excretion, fecal lipids, and steroids in a dose-dependent manner. In the second study, to examine the effects on cholesterol transport of redistribution of stearic acid in the triacylglycerol species contained in HSO, rats were given one of the six diets containing HSO (distearoylmonoacylglycerol and tristearoylglycerol)-rich, monostearoylglycerol-rich, or palmitic acid-rich oil with/without cholesterol (5 g/kg diet), for 30 d. Whereas the accumulation of cholesterol in the body was reduced, cholesterol excretion was enhanced effectively in rats given the HSO-rich diet compared with rats given the monostearoylglycerol-rich diet. These results suggested that not only the high concentration of stearic acid but also its uneven distribution in HSO-triacylglycerol contributed to the reduction in intestinal cholesterol absorption in rats.

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Abbreviations

Chl:

Cholesterol (in diets)

HSO:

highly hydrogenated soybean oil

HDL:

high-density lipoprotein

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Authors and Affiliations

  1. Laboratory of Nutritional Physiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, 543, Osaka, Japan

    Masaharu Kamei, Sumiko Ohgaki & Shigeru Morita

  2. Department of Domestic Sciences, Faculty of Education, Miyazaki University, 889-21, Miyazaki, Japan

    Tamotsu Kanbe

  3. Japan Institute of Oil and Fats, Other Foods Inspection, Foundation, 103, Tokyo, Japan

    Isao Niiya

  4. Ueda Oils and Fats Manufacturing Co., 658, Kobe, Japan

    Haruo Mizutani

  5. Department of Food and Nutrition, Faculty of Human Life Science, Osaka City University, 558, Osaka, Japan

    Isao Matsui-Yuasa

  6. Department of Biochemistry, Osaka City University, Medical School, 545, Osaka, Japan

    Shuzo Otani

Authors
  1. Masaharu Kamei
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  2. Sumiko Ohgaki
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  3. Tamotsu Kanbe
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  4. Isao Niiya
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  5. Haruo Mizutani
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  7. Shuzo Otani
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  8. Shigeru Morita
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Kamei, M., Ohgaki, S., Kanbe, T. et al. Effects of highly hydrogenated soybean oil and cholesterol on plasma, liver cholesterol, and fecal steroids in rats. Lipids 30, 533–539 (1995). https://doi.org/10.1007/BF02537028

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  • DOI: https://doi.org/10.1007/BF02537028

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