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Paf-acether in human skin

  • PAF and PAF Analogs and Their Metabolic Effects
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  • Published:
Lipids

Abstract

Paf is a phospholipid mediator present in human skin which induces inflammatory events such as neutrophil infiltration and increased vascular permeability. Recent data suggest that cutaneous cells, such as fibroblasts and keratinocytes, produce paf and that paf is released during allergic cutaneous reactions. It is tempting to speculate that paf may contribute to the development of various skin disorders with acute and chronic skin inflammation. Paf antagonists may help in bringing answers to this hypothesis and may offer new prospects for the treatment of cutaneous inflammatory diseases.

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Abbreviations

Acetyl-CoA:

acetyl-coenzyme A

IL1:

interleukin 1

lyso paf:

lyso paf-acether, 1-O-alkyl-sn-glycero-3-phosphocholine

paf:

paf-acether, 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine

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Author information

Author notes

  1. Yves Denizot

    Present address: Faculté de Médecine, C.J.F. INSERM 88-03, 2 rue du Docteur Marcland, 87025, Limoges, France

Authors and Affiliations

  1. INSERM U.312, 92010, Crèteil, France

    Laurence Michel & Louis Duberfret

  2. LVMH Recherche, 92704, Colombes, France

    Alain Meybeck

  3. INSERUM U.200, 32 rue des Carnets, 92140, Clamart, France

    Yves Denizot, Jacques Benveniste & Yolène Thomas

Authors
  1. Yves Denizot
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  2. Laurence Michel
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  3. Jacques Benveniste
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  4. Alain Meybeck
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  5. Yolène Thomas
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  6. Louis Duberfret
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Cite this article

Denizot, Y., Michel, L., Benveniste, J. et al. Paf-acether in human skin. Lipids 26, 1093–1094 (1991). https://doi.org/10.1007/BF02536508

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  • DOI: https://doi.org/10.1007/BF02536508

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