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Inositol phospholipid turnover in PAF transmembrane signalling

  • PAF and Signal Transduction
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  • Published:
Lipids

Abstract

In a variety of cells and tissues, platelet activating factor (PAF) stimulates phospholipase C catalyzed breakdown of phosphoinositides. This results in the generation of the second messengers, inositol trisphosphate and diglyceride. This process occurs independently of extracellular Ca2+. A number of PAF structural analogues, receptor antagonists and drugs have been utilized to pharmacologically probe the activation of phospholipase C. PAF stimulation of the phosphoinositide turnover was shown to be sensitive to pertussis toxin in some systems, but not in others. The involvement of guanine nucleotide binding protein(s) and tyrosine kinase(s) in this process have also been postulated. These developments give new insights into PAF-receptor function at the molecular level, and also provide leads towards a better understanding of the cellular responses to PAF.

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Abbreviations

AGEPC:

1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine

DG:

diglyceride

IP2 :

inositol diphosphate

IP3 :

inositol trisphosphate

IP4 :

inositol tetraphosphate

IP5 :

inositol pentaphosphate

IP6 :

inositol hexaphosphate

PA:

phosphatidic acid

PAF:

platelet activating factor

PMA:

phorbol myristate acetate

PI:

phosphatidylinositol

PIP:

phosphatidylinositol-4-phosphate

PIP2 :

phosphatidylinositol-4,5-bisphosphate

PKC:

protein kinase C

PLA2 :

phospholipase A2

PLC:

phospholipase C

PPI:

phosphoinositides

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  1. Department of Pharmacology, School of Medicine, University of Missouri, 65212, Columbia, MO

    Shivendra D. Shukla

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Shukla, S.D. Inositol phospholipid turnover in PAF transmembrane signalling. Lipids 26, 1028–1033 (1991). https://doi.org/10.1007/BF02536496

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  • DOI: https://doi.org/10.1007/BF02536496

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