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The effect of a histidine-excess diet on cholesterol synthesis and degradation in rats

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Lipids

Abstract

Feeding a diet high in excess histidine (5% L-histidine) resulted in hypercholesterolemia and enlargement of the liver in rats. To clarify the mechanism of the hypercho-lesterolemia cholesterol synthesis and degradation were followed. We found that hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in histidine-excess diet rats was significantly higher than in rats fed a basal diet. Incorporation of [3H]water into cholesterol of liver slices from rats fed the histidine-excess diet was higher than incorporation into liver slices from rats fed the basal diet (expressed per liver per 100 g body weight).In vivo incorporation of [3H]water into hepatic cholesterol was also higher, but the incorporation into cholesterol of the small intestine was lower in histidine-fed rats than in rats fed the basal diet (expressed per liver per 100 g body weight). Hepatic cholesterol 7α-hydroxylase activity was similar in both groups. The data suggest that the hypercholester-olemia caused by histidine-excess diet appears to be due to the stimulation of cholesterol synthesis in the liver.

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Abbreviations

EDTA:

ethylenediaminetetraacetic acid

HMG-CoA:

3-hydroxy-3-methylglutaryl-coenzyme A

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Authors and Affiliations

  1. Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, School of Agriculture, Nagoya University, 464-01, Nagoya, Japan

    Eri Hitomi-Ohmura, Nobuyuki Amano, Yoritaka Aoyama & Akira Yoshida

Authors
  1. Eri Hitomi-Ohmura
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  2. Nobuyuki Amano
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  3. Yoritaka Aoyama
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  4. Akira Yoshida
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Hitomi-Ohmura, E., Amano, N., Aoyama, Y. et al. The effect of a histidine-excess diet on cholesterol synthesis and degradation in rats. Lipids 27, 755–760 (1992). https://doi.org/10.1007/BF02535845

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  • DOI: https://doi.org/10.1007/BF02535845

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