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Stearoyl-CoA desaturase activity in adipose tissue and liver of the cardiomyopathic hamster

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Lipids

Abstract

Stearoyl-CoA desaturase activity and the fatty acid composition of lipids of adipose tissue and liver were determined in 35- and 180-day-old cardiomyopathic hamsters and age-matched normal controls. Enzyme activity was unchanged in the adipose tissue of 35-day-old animals but was significantly depressed in the 180-day-old cardiomyopathic hamsters. In the liver, stearoyl-CoA desaturase activity was significantly lower in the 35-day-old disease animals but was unchanged in the 180-day-old animals. The analysis of the fatty acid composition of the lipids isolated from adipose tissue showed an increase in the relative percentage of saturated fatty acids accompanied by a decrease in the relative percentage of unsaturated fatty acids in both age groups of the cardiomyopathic hamsters. However, linoleic acid content was increased in the diseased animals. Similar changes in fatty acid composition of lipids from the livers of 35-day-old cardiomyopathic hamsters were observed, but no significant differences in the fatty acid composition between 180-day-old cardiomyopathic hamsters and normal controls were observed. The changes in the fatty acid composition appear to be related to the observed changes in desaturase activity. In is concluded that such changes in desaturase activity and fatty acid composition could affect the normal structure and functions of membranes and membrane-related processes.

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Authors and Affiliations

  1. Biochemistry Department, East Carolina University Medical School, 27834, Greenville, North Carolina

    Hisham A. Barakat, William E. Brown & Sadhana Debnath

Authors
  1. Hisham A. Barakat
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  2. William E. Brown
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  3. Sadhana Debnath
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Barakat, H.A., Brown, W.E. & Debnath, S. Stearoyl-CoA desaturase activity in adipose tissue and liver of the cardiomyopathic hamster. Lipids 13, 622–626 (1978). https://doi.org/10.1007/BF02535827

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  • DOI: https://doi.org/10.1007/BF02535827

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