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Effects of dietary corn oil and salmon oil on lipids and prostaglandin E2 in rat gastric mucosa

  • Published:
Lipids

Abstract

Three groups of male rats were fed either a corn oilenriched diet (17%, w/w), a salmon oil-enriched diet (12.5%) supplemented with corn oil (4.5%) or a low-fat diet (4.4%) for eight wk to investigate the possible relationships between dietary fatty acids and lipid composition, and prostaglandin E2 level and phospholipase A2 activity in the rat gastric mucosa.

High-fat diets induced no important variation in total protein, phospholipid and cholesterol contents of gastric mucosa.

Compared with a low-fat diet, corn oil produced a higher n−6/n−3 ratio in mucosal lipids, whereas this ratio was markedly lowered by a fish oil diet.

In comparison with the low-fat diet, the production of prostaglandin E2(PGE2) in gastric mucosa of rats fed salmon oil was significantly, decreased by a factor of 2.8. In the corn oil group, PGE2 production tended to decrease, but not significantly.

In comparison with the low-fat diet, both specific and total gastric mucosal phospholipase A2 activities were increased (+18 and 23%, respectively) in the salmon oil group; they were unchanged in the corn oil group.

It is suggested that the decrease of gastric PGE2 in rats fed fish oil is not provoked by a decrease in phospholipase A2 activity but may be the result of the substitution of arachidonic acid by n−3 PUFA or activation of PGE2 catabolism.

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Abbreviations

FAME:

fatty acid methyl esters

PA2 :

phospholipase A2

PGE2 :

prostaglandin E2

PGI2 :

Prostacycline I2

PGI3 :

Prostacycline I3

PUFA:

polyunsaturated fatty acids

ANOVA:

analysis of variance

GLC:

gas liquid chromatography

P/S ratio:

polyun-saturated to saturated fatty acid ratio

RIA:

radioimmunoassay

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Authors and Affiliations

  1. INSERM Unité 130, 18 avenue Mozart, 13OO9, Marseille, France

    Renée Grataroli, Jeannie Léonardi, Monique Charbonnier, Huguette Lafont & Gilles Nalbone

  2. Laboratoire de Géologie du Quatemaire, CNRS, 13275, Marseille Cedex, France

    Raymond Lafont

Authors
  1. Renée Grataroli
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  2. Jeannie Léonardi
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  3. Monique Charbonnier
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  4. Raymond Lafont
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  5. Huguette Lafont
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  6. Gilles Nalbone
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Grataroli, R., Léonardi, J., Charbonnier, M. et al. Effects of dietary corn oil and salmon oil on lipids and prostaglandin E2 in rat gastric mucosa. Lipids 23, 666–670 (1988). https://doi.org/10.1007/BF02535665

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  • DOI: https://doi.org/10.1007/BF02535665

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